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SH2B3 encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. Additionally we are shipping SH2B3 Antibodies (70) and many more products for this protein.
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In conclusion, germ line LNK mutations rarely occur in familial myeloproliferative neoplasms (MPNs) and do not segregate with the disease phenotype. The findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2 (show JAK2 Proteins), CALR (show CALR Proteins), or MPL (show MPL Proteins) to determine disease phenotype in MPNs.
indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros (show IKZF1 Proteins) dysfunction
Elevated expression of Lnk in polycystic ovary syndrome suggests that Lnk probably plays a role in the development of insulin (show INS Proteins) resistance.
Hypercholesterolemia acts in platelets and hematopoietic progenitors to exacerbate thrombosis and atherosclerosis associated with SH2B3 deficiency.
The polymorphisms in LNK gene correlated to the clinical type of myeloproliferative neoplasms regardless of the JAK2 (show JAK2 Proteins) polymorphism.
SH2B3 mutations occur infrequently, and exon 8 in SH2B3 may be the most frequent mutational area in BCR-ABL (show ABL1 Proteins) negative myeloproliferative neoplasms patients in Korea.
LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension. Thus, LNK is a potential therapeutic target for this disease and its devastating consequences.
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 (show TSHZ1 Proteins).
results suggest that LNK suppresses IL-7R/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.
the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased celiac disease susceptibility (Meta-Analysis)
Lnk Deficiency Leads to TPO (show THPO Proteins)-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
Specific targeting of Lnk may be a promising EPC (show TCF21 Proteins)-based therapeutic strategy for dermal wound healing.
The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction.
We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion.
SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.
Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension.
Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues.
results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction.
IL-11 (show IL11 Proteins) therefore drives a pathway that enhances HSPC (show PSMA7 Proteins) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk.
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
lymphocyte adaptor protein
, SH2B adapter protein 3
, lymphocyte-specific adapter protein Lnk
, signal transduction protein Lnk
, linker of T-cell receptor pathways
, lymphocyte adapter protein