SH3 and Multiple Ankyrin Repeat Domains 2 Proteins (SHANK2)

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

• SH3 and multiple ankyrin repeat domains 2 (SHANK2)
• SH3 and multiple ankyrin repeat domains 2 (Shank2)
• SH3 and multiple ankyrin repeat domains 2 L homeolog (shank2.L)
• SH3 and multiple ankyrin repeat domains 2 (shank2)
• SH3 and multiple ankyrin repeat domains protein 2 (LOC100438523)

• auts17 protein
• CortBP1 protein
• cttnbp1 protein
• MGC122482 protein
• mKIAA1022 protein
• Show all synonym aliases
• prosap1 protein
• SHANK protein
• SHANK2 protein
• Spank-3 protein

GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , cortBP1 , SH3 and multiple ankyrin repeat domains 2 , SH3/ankyrin domain gene 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP-interacting protein , proline rich synapse associated protein 1