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SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Additionally we are shipping SHANK2 Antibodies (187) and many more products for this protein.
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This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
GKAP/SAPAP interacting protein
, SH3 and multiple ankyrin repeat domains protein 2
, cortactin SH3 domain-binding protein
, cortactin-binding protein 1
, proline-rich synapse associated protein 1
, proline-rich synapse-associated protein 1
, SH3 and multiple ankyrin repeat domains 2
, SH3/ankyrin domain gene 2
, SH3 and multiple ankyrin repeat domains protein 2-like
, GKAP/SAPAP-interacting protein
, proline rich synapse associated protein 1