SH3 and Multiple Ankyrin Repeat Domains 2 Proteins (SHANK2)

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Additionally we are shipping SHANK2 Antibodies (185) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SHANK2 22941 Q9UPX8
SHANK2 210274 Q80Z38
Rat SHANK2 SHANK2 171093 Q9QX74
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Top SHANK2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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SHANK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. We report a deletion including the SHANK2 gene in a female child with dysmorphic features, microcephaly, and global developmental delay, providing additional evidence for SHANK2 involvement in intellectual disability

  2. In one family, seven siblings with schizophrenia spectrum disorders each carry a novel private missense variant within the SHANK2 gene.

  3. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla

  4. variants in the SHANK2 gene in a schizophrenia patient cohort

  5. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (show CFTR Proteins).

  6. syndapin I (show PACSIN1 Proteins) functions reflected direct, SH3 domain (show ITSN1 Proteins)-mediated associations and functional interactions with ProSAP1/Shank2.

  7. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

  8. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate receptors at the synapse and increased levels of ProSAP2/Shank3

  9. we confirmed that de novo SHANK2 deletions are present in patients with ASD (show ARSD Proteins) and showed that several SHANK2 variants reduce the number of synapses in vitro

  10. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (show ARSD Proteins)

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. The results indicate that SHANK2 is crucial for parallel fiber-Purkinje cell long-term potentiation, but not long-term depression. In addition, SHANK2 is important for intrinsic plasticity of neuronal excitability.

  2. location memory acquired in a head-fixed virtual environment. Encoding and updating of virtual cued goal location memory was impaired in Shank2-deficient mice that mimic a deletion found in human autistic patients and exhibit impaired spatial learning in a real environment. These results highlight the roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in virtual reality.

  3. Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK (show EPHB2 Proteins) signaling in spinal pain transmission.

  4. We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors.

  5. Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.

  6. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice

  7. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  8. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  9. syndapin I (show PACSIN1 Proteins) functions reflected direct, SH3 domain (show ITSN1 Proteins)-mediated associations and functional interactions with ProSAP1/Shank2.

  10. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

SHANK2 Protein Profile

Protein Summary

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Gene names and symbols associated with SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2)
  • SH3 and multiple ankyrin repeat domains 2 (Shank2)
  • SH3 and multiple ankyrin repeat domains 2 L homeolog (shank2.L)
  • SH3 and multiple ankyrin repeat domains 2 (shank2)
  • SH3 and multiple ankyrin repeat domains protein 2 (LOC100438523)
  • auts17 protein
  • CortBP1 protein
  • cttnbp1 protein
  • MGC122482 protein
  • mKIAA1022 protein
  • prosap1 protein
  • SHANK protein
  • SHANK2 protein
  • Spank-3 protein

Protein level used designations for SHANK2

GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , cortBP1 , SH3 and multiple ankyrin repeat domains 2 , SH3/ankyrin domain gene 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP-interacting protein , proline rich synapse associated protein 1

GENE ID SPECIES
22941 Homo sapiens
210274 Mus musculus
428858 Gallus gallus
483677 Canis lupus familiaris
734458 Xenopus laevis
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
171093 Rattus norvegicus
466694 Pan troglodytes
618649 Bos taurus
708192 Macaca mulatta
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
100732196 Cavia porcellus
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