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Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Additionally we are shipping SH3BP1 Antibodies (57) and and many more products for this protein.
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Study demonstrated a high SH3BP1 expression in cervical cancer tissues and correlated with a shorter overall survival. Its expression is even higher in cisplatin resistant cervical neoplasm tissues compared to that of the cisplatin-sensitive ones. Furthermore, SH3BP1 plays an important role in the regulation of cervical cancer cell invasion, migration, and chemoresistance through Rac1/Wav2.
SH3BP1 promoted VEGF (show VEGFA Proteins) secretion via Rac1-WAVE2 (show WASF2 Proteins) signaling, so as to exert an augmentation on cell invasion and microvessel formation.
The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E (show SEMA3E Proteins)-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior.
Splicing of SH3BP1 and CIN (show PDXP Proteins) gene loci produces the novel brain specific (show CALY Proteins) splice variant BGIN.
Epithelial junction formation and morphogenesis require a dual activity complex, containing SH3BP1 and CapZ (show CAPZA1 Proteins), that is recruited to sites of active membrane remodeling to guide Cdc42 (show CDC42 Proteins) signaling and cytoskeletal dynamics.
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
, SH3 domain binding protein 1
, SH3 domain-binding protein 1
, SH3-domain binding protein 1
, SH3 domain-binding protein 1-like