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SIGLEC11 encodes a member of the sialic acid-binding immunoglobulin-like lectin family. Additionally we are shipping SIGLEC11 Proteins (3) and SIGLEC11 Kits (1) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal SIGLEC11 Primary Antibody for FACS - ABIN4895909
Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. in Scientific reports 2016
Human Polyclonal SIGLEC11 Primary Antibody for FACS, WB - ABIN4899316
Wang, Chow, Deng, Anderson, Weidner, Godwin, Bewtra, Zlotnik, Bui, Varki, Varki: Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. in Glycobiology 2011
The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.
The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution.
Siglec-11 ectopically expressed on murine microglia interacts with PSA (show PLAG1 Antibodies) on neurons, reduces LPS (show IRF6 Antibodies)-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.
cloning and characterization; a recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages including brain microglia
expressed in human but not in chimpanzee brain microglia; findings indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene
SIGLEC16 encodes a DAP12 (show TYROBP Antibodies)-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
sialic acid-binding Ig-like lectin 11
, sialic acid binding Ig-like lectin 11
, sialic acid-binding Ig-like lectin 11-like