anti-Signal-Regulatory Protein alpha (SIRPA) Antibodies

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Additionally we are shipping SIRPA Proteins (36) and SIRPA Kits (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Top anti-SIRPA Antibodies at antibodies-online.com

Showing 10 out of 205 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIRPA Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Pig Mouse FITC FACS 0.1 mg Log in to see 6 to 8 Days
$775.50
Details
Human Rabbit Un-conjugated IC, IF, IP, WB Immunofluorescent analysis of CD172a staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of CD172a expression in THP1 (A), AML193 (B), HL60 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 11 Days
$522.50
Details
Human Rabbit Un-conjugated IP, ELISA 100 μL Log in to see 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells, using Sirp alpha1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Sirp alpha1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human 293T Cells; Lane2: Porcine Brain Tissue. Figure. Western Blot; Sample: Recombinant SIRPa, Human. 100 μg Log in to see 13 to 16 Days
$316.00
Details
Rat Mouse FITC FACS ABIN119468 staining of rat peritoneal macrophages 0.1 mg Log in to see 6 to 8 Days
$467.50
Details
Rat Mouse PE FACS ABIN119470 staining of rat peritoneal macrophages. 100 Tests Log in to see 6 to 8 Days
$555.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see Available
$363.46
Details

Top referenced anti-SIRPA Antibodies

  1. Mouse (Murine) Monoclonal SIRPA Primary Antibody for BR, FACS - ABIN2689017 : Chuang, Lagenaur: Central nervous system antigen P84 can serve as a substrate for neurite outgrowth. in Developmental biology 1990 (PubMed)
    Show all 7 Pubmed References

  2. Cow (Bovine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478782 : : Epoetin--an important advance. in Drug and therapeutics bulletin 1992 (PubMed)
    Show all 4 Pubmed References

  3. Cow (Bovine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478783 : Howard, Brooke, Werling, Sopp, Hope, Parsons, Collins: Dendritic cells in cattle: phenotype and function. in Veterinary immunology and immunopathology 2000 (PubMed)
    Show all 4 Pubmed References

  4. Pig (Porcine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478797 : Dutkiewicz, Stepie?, Witeska: [Diagnostic value of prostatic specific antigen (PSA) in comparison to prostatic acid phosphatase (PAP) in prostatic cancer and adenoma]. in Wiadomo?ci lekarskie (Warsaw, Poland : 1960) 1993 (PubMed)
    Show all 4 Pubmed References

  5. Pig (Porcine) Monoclonal SIRPA Primary Antibody for IHC (fro), FACS - ABIN2478796 : Bullido, Pérez de la Lastra, Almazán, Ezquerra, Llanes, Alonso, Domínguez: Induction of aggregation in porcine lymphoid cells by antibodies to CD46. in Veterinary immunology and immunopathology 2000 (PubMed)
    Show all 4 Pubmed References

  6. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS, IHC (fro) - ABIN260107 : Lazo, Klein-Szanto, Tsichlis: T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. in Journal of virology 1990 (PubMed)
    Show all 3 Pubmed References

  7. Human Monoclonal SIRPA Primary Antibody for IHC (fro), FACS - ABIN2478785 : Murray: A field investigation of causes of abortion in dairy cattle. in The Veterinary record 1991 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal SIRPA Primary Antibody for FACS - ABIN2478787 : Fujioka, Matozaki, Noguchi, Iwamatsu, Yamao, Takahashi, Tsuda, Takada, Kasuga: A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. in Molecular and cellular biology 1997 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal SIRPA Primary Antibody for FACS - ABIN2478795 : van Beek, Cochrane, Barclay, van den Berg: Signal regulatory proteins in the immune system. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 3 Pubmed References

More Antibodies against SIRPA Interaction Partners

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. QPCTL is critical for pyroglutamate formation on CD47 at the SIRPalpha binding site shortly after biosynthesis.

  2. Accumulation of SIRPalpha-inhibited macrophages in tumors favored tumor regression for 1-2 weeks, but donor macrophages quickly differentiated toward non-phagocytic, high-SIRPalpha TAMs.

  3. SIRP alpha protein is under-expressed in low and high-grades of astrocytoma from patients' brain samples.

  4. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  5. SIRPalpha might play an important role in the progression of oral leukoplakia and oral cancer, and could be a pivotal therapeutic target in oral squamous cell carcinoma, regulating the phenotype of macrophages via targeting NF-kappaB signaling.

  6. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

  7. data suggest that TTI-621 may be efficacious in triggering the destruction of cancer cells by a diverse population of TAMs found in vivo and support possible combination approaches to augment the activity of CD47 blockade

  8. CD47, TSP1, and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  9. exploited by Hepatitis E virus to negative regulated IFN-beta of the host innate immune system to promote viral infection

  10. Data suggest a reduction in the CD47 antigen/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  11. agents that block the CD47:SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  12. the data suggest that combinatorial actions of ADAM10 and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  13. Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  14. Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  15. negatively regulates neutrophil accumulation during inflammation

  16. Combinatorial expression of NKX2-5, SIRPA, VCAM1 and CD34 can be used to define discrete stages of cardiovascular cell lineage differentiation.

  17. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG.

  18. These results suggest that thrombospondin-1 binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase, limits vasodilation, and promotes renal ischemia reperfusion injury.

  19. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 and initiate intracellular signaling

  20. Polymorphisms in the human inhibitory signal-regulatory protein alpha do not affect binding to its ligand CD47.

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. Data indicate that only signal regulatory protein alpha (SIRPalpha+) CD8(+) T cells actively proliferate and show cytolytic activity.

  2. Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma.

  3. Tyrosine phosphorylation of SIRPalpha is necessary for SIRPalpha cleavage and presynaptic maturation.

  4. Accumulation of SIRPalpha-inhibited macrophages in tumors favored tumor regression for 1-2 weeks, but donor macrophages quickly differentiated toward non-phagocytic, high-SIRPalpha TAMs.

  5. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  6. SIRPalpha-expressing dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult mouse spleen.

  7. CCR7 deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation.

  8. Mechanistic studies suggest a PKC-Syk-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.

  9. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  10. Data provide evidence that SIRPalpha-mediated phagocytosis is not a major determinant in prion disease pathogenesis.

  11. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA interaction and Rac1/Akt activation.

  12. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells.

  13. These results indicate an important role for CD47-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.

  14. TLR5 mediates CD172a(+) intestinal lamina propria dendritic cell induction of Th17 cells.

  15. a novel and opposite contribution of SIRPalpha signaling within non-hematopoietic and hematopoietic cells

  16. These findings demonstrate, for the first time, that SIRPalpha signaling can directly control phagocyte migration.

  17. SIRPalpha intrinsic to CD11c(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  18. Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  19. data identified SIRPalpha signaling in non-hematopoietic cells to play an important role in regulating the numbers and positioning MZB cell in the spleen

  20. Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

SIRPA Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal regulatory protein alpha (SIRPA) antibody
  • signal-regulatory protein alpha (SIRPA) antibody
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039) antibody
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378) antibody
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224) antibody
  • signal-regulatory protein alpha (Sirpa) antibody
  • AI835480 antibody
  • Bit antibody
  • CD172a antibody
  • MFR antibody
  • MYD-1 antibody
  • P84 antibody
  • Ptpns1 antibody
  • SHP-1 antibody
  • SHPS-1 antibody
  • SHPS1 antibody
  • SIRP antibody
  • SIRP-A1 antibody
  • SIRP-B1 antibody
  • SIRPA antibody
  • swc3 antibody

Protein level used designations for SIRPA

CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , MyD-1 antigen , SHP substrate 1 , SHPS-1 , protein tyrosine phosphatase, non-receptor type substrate 1 , signal-regulatory protein alpha-1 , sirp-alpha-1 , signal-regulatory protein alpha , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen

GENE ID SPECIES
140885 Homo sapiens
327666 Bos taurus
419267 Gallus gallus
458039 Pan troglodytes
609452 Canis lupus familiaris
717811 Macaca mulatta
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
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