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SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. Additionally we are shipping SIM1 Proteins (3) and many more products for this protein.
Showing 10 out of 43 products:
Human Polyclonal SIM1 Primary Antibody for ELISA, WB - ABIN4353806
Ghoussaini, Stutzmann, Couturier, Vatin, Durand, Lecoeur, Degraeve, Heude, Tauber, Hercberg, Levy-Marchal, Tounian, Weill, Traurig, Bogardus, Baier, Michaud, Froguel, Meyre: Analysis of the SIM1 contribution to polygenic obesity in the French population. in Obesity (Silver Spring, Md.) 2010
SIM1 was highly methylated in the majority of the cervical cancer tissues. Hypermethylation of SIM1 led to a pronounced reduction in SIM1 expression in cervical cancer tissues compared with normal cervix. The degree of SIM1 methylation was significantly associated with the severity of the disease.
Single nucleotide polymorphism rs3734354 in SIM1 gene is associated with severe early-onset obesity.
identified a novel SIM1 variant, p.D134N, in 4 obese individuals from a single pedigree which is also associated with lower preference for certain foods
no gene harboring deletions were identified in the SIM1 and MRAP2 regions in the Prader Willi like (PWL) cohort; further functional analysis of p.P352S found in SIM1 and p.A40S found in MRAP2 is useful; this would provide further support for possible role of SIM1 and MRAP2 in the pathogenesis of the PWL phenotype in a limited number of patients
Genotype-phenotype correlations confirmed the major role for SIM1 haploinsufficiency in obesity and the Prader-Willi-like phenotype
Aberrant DNA methylation (show HELLS Antibodies) of the DLX4 (show DLX4 Antibodies) and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions.
Severe loss-of-function SIM1 mutations can be associated with a spectrum of developmental delay phenotypes and obesity.
functional in vitro analysis of SIM1 variants may help in distinguishing benign variants of no pathogenic significance from variants which contribute to the obesity phenotype.
Study found a statistically significant association between the SIM1 SNP rs3734354 (Pro352Thr) and scores for language impairment (p = .0004), but due to low statistical power this should be interpreted cautiously
two brain enhancers in the SIM1 locus are characterized with a set of obesity-specific SNPs within one of them, which may predispose individuals to obesity.
Data (including data from studies in knockout mice) suggest that expression of Mc4r (show MC4R Antibodies) in Sim1 neurons of arcuate nucleus of hypothalamus, paraventricular hypothalamic nucleus, and amygdala is involved in sexual function; here, expression of Mc4r (show MC4R Antibodies) only on Sim1 neurons reverses sexual deficits seen in Mc4r (show MC4R Antibodies) null mice. (Mc4r (show MC4R Antibodies) = melanocortin 4 receptor (show MC4R Antibodies); Sim1 = single-minded homolog 1)
Results demonstrate that Sim1 is essential for proper migration and the guidance of commissural axons of the spinal V3 interneurons
These findings reveal Sim1 as a critical yet previously unrecognized modulator of skeletal homeostasis that functions through a central relay.
CB1 (show CNR1 Antibodies) receptors on Sim1-positive neurons do not impact food intake but hinder energy expenditure during dietary environmental challenges that promote body weight gain.
Results show that Sim1 acts physiologically as well as developmentally to regulate body weight.
Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.
Sim1 neurons in adult mice regulate both food intake and energy expenditure
Sim1 is a regulator of dorsal raphe nucleus specification acting upstream of Pet1 (show FEV Antibodies) and Tph2 (show TPH2 Antibodies).
Sim1 haploinsufficiency is thus associated with a decrease of several paraventricular nucleus and supraoptic nucleus of the hypothalamus cell types, which has the potential of affecting distinct homeostatic processes.
Differential activities of murine single minded 1 (SIM1) and SIM2 (show SIM2 Antibodies) on a hypoxic response element
Data indicate that nephron proximal tubule patterning is reliant on sim1a transcription factor activity.
Sim1a contributes to control of lateral positioning of longitudinal hypothalamic-spinal axons by negative regulation of robo3a (show ROBO3 Antibodies).1 expression, which in turn attenuates the repulsive activity of Robo2 (show ROBO2 Antibodies).
role of sim1 in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals
Results describe the ontogeny of vasotocin (show AVP Antibodies)-expressing cells in zebrafish, and the selective requirement for the transcriptional regulators orthopedia (show OTP Antibodies) and single-minded 1 in the preoptic area.
commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 (show OLIG2 Antibodies) and its downstream neuronal specific effector Sim1
three SIM1 genotypes (CC, CT, TT) were found and their frequencies between domestic and foreign breeds were different
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.
class E basic helix-loop-helix protein 14
, single-minded homolog 1
, single-minded 1
, single-minded-like 1