anti-Sirtuin 3 (SIRT3) Antibodies

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (30) and SIRT3 Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top anti-SIRT3 Antibodies at antibodies-online.com

Showing 10 out of 238 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT3 antibody (ABIN390178) in Y79 cell line lysates (35 µg/lane). SIRT3 (arrow) was detected using the purified polyclonal antibody. 400 μL 10 to 11 Days
$385.00
Details
Cow Rabbit Un-conjugated IHC, WB Human kidney WB Suggested Anti-SIRT3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185498 (0.2µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Hamster Rabbit Un-conjugated IHC (p), WB Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in mouse brain tissue lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in CHO cell line lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. 200 μL 10 to 11 Days
$385.00
Details
Mouse Goat Un-conjugated ELISA, FACS, IF, WB ABIN768568 (0.3µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN768568 Immunofluorescence analysis of paraformaldehyde fixed NIH3T3 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIRT3 Antibody   Titration: 5 ug/ml   Positive Control: Fetal thymus 100 μL 2 to 3 Days
$229.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-SIRT3 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$249.00
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using SIRT3 mAb against human SIRT3 (AA: 155-290) recombinant protein. (Expected MW is 41.3 kDa) Dilution: 1/500 - 1/2000 100 μL 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated WB Anti-SIRT3 Picoband antibody,  All lanes: Anti SIRT3  at 0.5ug/ml WB: Recombinant Human SIRT3 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Anti-SIRT3 Picoband antibody, All lanes: Anti SIRT3  at 0.5ug/ml Lane 1: Rat Spleen Tissue Lysate at 50ug Lane 2: Human Placenta Tissue Lysate at 50ug Lane 3: HELA Whole Cell Lysate at 40ug Lane 4: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 44KD  Observed bind size: 44KD 100 μg 4 to 6 Days
$240.00
Details

Top referenced anti-SIRT3 Antibodies

  1. Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178 : Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal SIRT3 Primary Antibody for WB - ABIN549536 : Werner, Kuhlmann, Shen, Uecker, Schardt, Dimova, Orfaniotou, Dhaunchak, Brinkmann, Möbius, Guarente, Casaccia-Bonnefil, Jahn, Nave: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)
    Show all 3 Pubmed References

  3. Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610 : Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822 : Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 Pubmed References

  5. Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184 : Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SIRT3 Primary Antibody for IF, IHC - ABIN6147792 : Xu, Gao, Zhang, Wei, Chen, Dai, Zeng, Zhao: SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. in Oxidative medicine and cellular longevity 2017 (PubMed)

  7. Human Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN6147791 : Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  8. Human Polyclonal SIRT3 Primary Antibody for ELISA, ICC - ABIN6265092 : Li, Chen, Yang, He, He, Xia, Zhang, Xiang: Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3. in International journal of oncology 2018 (PubMed)

More Antibodies against SIRT3 Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. SIRT3 promoted mitochondrial biogenesis by increasing both the expression and deacetylation of TFAM in clear cell renal cell carcinoma.

  2. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

  3. Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death.

  4. High SIRT3 expression is associated with diabetes and hypothyroidism.

  5. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

  6. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

  7. The Sirt3-mediated protein deacetylation plays an important role in regulating oxidative metabolism and antioxidant defence in stem cell differentiation, and that Sirt3 deficiency may be related to insulin resistance.

  8. SIRT3 gene expression is altered in adipose tissue from overweight and obese subjects compared to normal weight subjects.

  9. MiR-494-3p inhibition exerted a neuroprotective role in 1-Methyl-4-phenylpyridinium induced Parkinson's disease by targeting SIRT3, providing a possible therapeutic strategy for Parkinson's disease patients.

  10. ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.

  11. The SIRT3 promoted FOXO3A expression by attenuating Wnt/beta-catenin pathway, thereby inhibiting EMT and migration of prostate cancer cells.

  12. Sirtuin-3 mitochondrial NAD-dependent deacetylase (SIRT3) is responsible for serine hydroxymethyltransferase 2 (SHMT2)deacetylation in colorectal cancer (CRC) cells. The increased expression of SIRT3 in human CRC samples is correlated with poorer postoperative overall survival.

  13. genetic manipulation of Sirt3 revealed that amyloid-beta increased levels of total tau acetylated tau through its modulation of Sirt3.

  14. The SIRT3 protein level negatively correlated with advanced glycation end products accumulation and the grade of intervertebral disc degeneration degeneration.

  15. Melatonin's functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. [review]

  16. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls.

  17. BER modulated autophagy in DOX-treated H9c2 cardiomyoblasts. Interestingly, mitochondrial biogenesis markers were upregulated in in BER/DOX-treated cells. Sirt3 over-expression contributes to decrease DOX cytotoxicity on H9c2 cardiomyoblasts, while BER can be used as a modulator of Sirtuin function and cell quality control pathways to decrease DOX toxicity.

  18. The loss of Sirt3 triggered fatal mitochondrial fission by suppressing the Akt/PTEN pathway.

  19. Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation.

  20. De novo expression of transfected Sirt3 enhances susceptibility of human epithelial breast cancer cells to hyperoxia treatment.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. The role of SIRT3 in the development of nonalcoholic fatty liver disease, impaired intestinal permeability and gut microbiota dysbiosis.

  2. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

  3. Findings suggest that adipocyte SIRT3 is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.

  4. The level of Sirt3 in cerebral infarct region is decreased after ischemic stroke.

  5. Sirt3 deficiency aggravates contrast-induced acute kidney injury.

  6. Study provides evidence that neuronal networks in the hippocampus of mice adapt to intermittent food deprivation by up-regulating GABAergic inhibitory neurotransmission via a mechanism requiring SIRT3 and involving a reduction in mitochondrial oxidative stress.

  7. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

  8. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

  9. Study results demonstrated that Sirt3 was downregulated in cartilage chondrocytes from IL-1beta induced osteoarthritis mouse model and Sirt3 expression is associated with the progression of osteoarthritis, it is also involved in the clearance of dysfunctional mitochondria via mitophagy in chondrocytes.

  10. long-term potentiation was impaired in the Sirt3-knockout mice

  11. The data of this study suggested that Sirt3 KO mice show neuroprotection by a compensatory rise in Sirt1 rather than the loss of Sirt3 after stroke.

  12. these results established the SIRT3-Foxo3a-catalase pathway as a critical factor in the maintenance of endothelial homeostasis and point to an important role of EndoMT in the vascular pathology of renal fibrosis, which may provide a new therapeutic target to impede the progression of hypertensive renal injury.

  13. study demonstrated that SIRT3 deficiency exacerbated CCl 4 -induced impairment of the liver in mice, and the mechanism might be related to enhanced oxidative stress.

  14. Studied antiobesity effect of myricetin in adipose tissue and found effect is mediated thru upregulation of sirtuin 3 (SIRT3).

  15. our data revealed that Sirt3 is an anti-inflammatory and tumor-suppressing gene that interacts with the gut microbiota during colon tumorigenesis.

  16. these findings identify a protective role of SIRT3 against angiotensin II-induced epithelial-mesenchymal transition in the kidney.

  17. genetic manipulation of Sirt3 revealed that amyloid-beta increased levels of total tau acetylated tau through its modulation of Sirt3.

  18. data indicate a specific action of the shorter SIRT3 isoform on lipid mitochondrial membrane biosynthesis and functioning.

  19. Using the cre-loxP system, we overexpressed the mitochondrial NAD(+) dependent protein deacetylase SIRT3 in enterocytes of mice (iSIRT3 mice). We chronically fed iSIRT3 mice and floxed-SIRT3 control (S3fl) mice a low-fat, control diet (CD) or a high-fat diet (HFD) and then phenotyped the mice. There were no genotype differences in any of the parameters tested when the mice were fed CD.

  20. the protective effects of Polydatin are associated with the up-regulation of autophagy and improvement of mitochondrial biogenesis through Sirt3 activity.

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.

  2. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  3. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  4. The expression profile of sirtuin 1 and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with anti-Sirtuin 3 (SIRT3) Antibodies

  • sirtuin 3 (sirt3) antibody
  • sirtuin 3 (SIRT3) antibody
  • sirtuin 3 (Sirt3) antibody
  • 2310003L23Rik antibody
  • AI848213 antibody
  • Sir2l3 antibody
  • sirtuin antibody
  • zgc:158774 antibody

Protein level used designations for anti-Sirtuin 3 (SIRT3) Antibodies

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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