anti-Sirtuin 3 (SIRT3) Antibodies

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (27) and SIRT3 Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top anti-SIRT3 Antibodies at antibodies-online.com

Showing 10 out of 236 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT3 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Human Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT3 antibody (ABIN390178) in Y79 cell line lysates (35 µg/lane). SIRT3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-SIRT3 Antibody Titration: </b>2.5ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185498 (0.2µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated WB Anti-SIRT3 Picoband antibody,  All lanes: Anti SIRT3  at 0.5ug/ml WB: Recombinant Human SIRT3 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Observed bind size: 44KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A549, using SIRT3, antibody at 1:200 dilution. IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SIRT3, antibody at 1:500 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Hamster Rabbit Un-conjugated IHC (p), WB Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in mouse brain tissue lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in CHO cell line lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details

SIRT3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIRT3 Antibodies

  1. Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178 : Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010 (PubMed)
    Show all 11 Pubmed References

  2. Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610 : Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822 : Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 Pubmed References

  4. Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184 : Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SIRT3 Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. This study investigated the role of SIRT3 in MSC (show MSC Antibodies) differentiation and aging. As MSCs were expanded ex vivo, SIRT3 levels decreased. In addition, SIRT3 depletion reduced MSC (show MSC Antibodies) differentiation into adipocytes and osteoblasts. Overexpression of SIRT3 in later-passage MSCs reduced aging-related senescence, reduced oxidative stress, and enhanced their ability to differentiate.

  2. UCP2 (show UCP2 Antibodies) regulates the activity of SIRT3 through sensing the energy level and, in turn, maintaining the mitochondrial steady state, which demonstrates a cytoprotective effect on ischemia-reperfusion injury.

  3. Authors have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC.

  4. SIRT3 could enhance the drug sensitivity of hepatoma cells to an array of chemotherapeutic agents through glutathione S-transferase pi 1 (show GSTP1 Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway

  5. Data suggest that pharmacological approaches for augmenting sirtuin 3 (SIRT3) might have therapeutic potential in organ fibrosis in systemic sclerosis (SSc (show CYP11A1 Antibodies)).

  6. Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells.

  7. Contrary to what has been known in solid tumors, in K562 human leukemia cells, Sirt3 plays an opposite role in relieving oxidative stress. Basal but not enhanced autophagy activity maintains ubiquitination-proteasomal degradation of Sirt3 to limit reactive oxygen species level.

  8. SIRT3 whole muscle protein content was unaltered after fasting.

  9. Current study reveal Sirt3 as a novel regulator coupling mitophagy and apoptosis, two important cellular processes that determine cellular survival and death.

  10. The function of the three mitochondrial sirtuins (SIRT3, SIRT4 (show SIRT4 Antibodies), SIRT5 (show SIRT5 Antibodies)) and their role in disease are reviewed.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. EphB2 (show EPHB2 Antibodies) signaling-mediated Sirt3 expression reduces mesenchymal stem cells senescence by maintaining mitochondrial reactive oxygen species homeostasis.

  2. Sirt3 plays a protective role against oxidative stress in oocytes exposed to maternal diabetes through deacetylating SOD2K68.

  3. our findings implicate that a novel SIRT3-KLF15 (show KLF15 Antibodies) signaling may prevent kidney injury from hypertension and HKL can act as a SIRT3-KLF15 (show KLF15 Antibodies) signaling activator to protect against hypertensive nephropathy.

  4. Study provides evidence that present that Sirt3 expression protected pancreatic beta cells from lipotoxicity by antagonizing oxidative stress-induced (show SQSTM1 Antibodies) cell damage.

  5. Sirt3 activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1 (show FOXO1 Antibodies), which in turn alleviates myocardial hypertrophy.

  6. The authors provide evidence that inactivation of PIKfyve (show PIKFYVE Antibodies) by the selective inhibitor STA (show SULT2A1 Antibodies) suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.

  7. the regulation of mitochondrial ROS (show ROS1 Antibodies) by SOD2 (show SOD2 Antibodies) and Sirt3 plays an important role in fine-tuning the Osteoclast differentiation program.

  8. conclude that Sirt3 does not considerably impact NET formation, platelet function, or venous thrombosis in healthy young mice

  9. vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK (show PRKAA1 Antibodies) phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK (show PRKAA1 Antibodies)/autophagy network orchestrates in the protective effect of resveratrol in macrophages.

  10. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (show PGC Antibodies)-1a-SOD2 (show SOD2 Antibodies)-mediated regulation of mitochondrial function

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  2. The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  3. The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with anti-Sirtuin 3 (SIRT3) Antibodies

  • sirtuin 3 (sirt3) antibody
  • sirtuin 3 (SIRT3) antibody
  • sirtuin 3 (Sirt3) antibody
  • 2310003L23Rik antibody
  • AI848213 antibody
  • Sir2l3 antibody
  • sirtuin antibody
  • zgc:158774 antibody

Protein level used designations for anti-Sirtuin 3 (SIRT3) Antibodies

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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