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SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (27) and SIRT3 Proteins (16) and many more products for this protein.
Showing 10 out of 236 products:
Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178
Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010
Show all 11 Pubmed References
Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610
Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 4 Pubmed References
Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822
Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005
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Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184
Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010
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This study investigated the role of SIRT3 in MSC (show MSC Antibodies) differentiation and aging. As MSCs were expanded ex vivo, SIRT3 levels decreased. In addition, SIRT3 depletion reduced MSC (show MSC Antibodies) differentiation into adipocytes and osteoblasts. Overexpression of SIRT3 in later-passage MSCs reduced aging-related senescence, reduced oxidative stress, and enhanced their ability to differentiate.
UCP2 (show UCP2 Antibodies) regulates the activity of SIRT3 through sensing the energy level and, in turn, maintaining the mitochondrial steady state, which demonstrates a cytoprotective effect on ischemia-reperfusion injury.
Authors have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC.
SIRT3 could enhance the drug sensitivity of hepatoma cells to an array of chemotherapeutic agents through glutathione S-transferase pi 1 (show GSTP1 Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway
Data suggest that pharmacological approaches for augmenting sirtuin 3 (SIRT3) might have therapeutic potential in organ fibrosis in systemic sclerosis (SSc (show CYP11A1 Antibodies)).
Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells.
Contrary to what has been known in solid tumors, in K562 human leukemia cells, Sirt3 plays an opposite role in relieving oxidative stress. Basal but not enhanced autophagy activity maintains ubiquitination-proteasomal degradation of Sirt3 to limit reactive oxygen species level.
SIRT3 whole muscle protein content was unaltered after fasting.
Current study reveal Sirt3 as a novel regulator coupling mitophagy and apoptosis, two important cellular processes that determine cellular survival and death.
The function of the three mitochondrial sirtuins (SIRT3, SIRT4 (show SIRT4 Antibodies), SIRT5 (show SIRT5 Antibodies)) and their role in disease are reviewed.
EphB2 (show EPHB2 Antibodies) signaling-mediated Sirt3 expression reduces mesenchymal stem cells senescence by maintaining mitochondrial reactive oxygen species homeostasis.
Sirt3 plays a protective role against oxidative stress in oocytes exposed to maternal diabetes through deacetylating SOD2K68.
our findings implicate that a novel SIRT3-KLF15 (show KLF15 Antibodies) signaling may prevent kidney injury from hypertension and HKL can act as a SIRT3-KLF15 (show KLF15 Antibodies) signaling activator to protect against hypertensive nephropathy.
Study provides evidence that present that Sirt3 expression protected pancreatic beta cells from lipotoxicity by antagonizing oxidative stress-induced (show SQSTM1 Antibodies) cell damage.
Sirt3 activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1 (show FOXO1 Antibodies), which in turn alleviates myocardial hypertrophy.
The authors provide evidence that inactivation of PIKfyve (show PIKFYVE Antibodies) by the selective inhibitor STA (show SULT2A1 Antibodies) suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.
the regulation of mitochondrial ROS (show ROS1 Antibodies) by SOD2 (show SOD2 Antibodies) and Sirt3 plays an important role in fine-tuning the Osteoclast differentiation program.
conclude that Sirt3 does not considerably impact NET formation, platelet function, or venous thrombosis in healthy young mice
vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK (show PRKAA1 Antibodies) phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK (show PRKAA1 Antibodies)/autophagy network orchestrates in the protective effect of resveratrol in macrophages.
Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (show PGC Antibodies)-1a-SOD2 (show SOD2 Antibodies)-mediated regulation of mitochondrial function
The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.
The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
, NAD-dependent deacetylase sirtuin-3, mitochondrial
, NAD-dependent protein deacetylase sirtuin-3, mitochondrial
, SIR2-like protein 3
, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
, regulatory protein SIR2 homolog 3
, silent mating type information regulation 2, S.cerevisiae, homolog 3
, sir2-like 3
, sirtuin type 3
, SIRT3 mitochondrial
, NAD-dependent deacetylase sirtuin-3
, NAD-dependent protein deacetylase sirtuin-3
, SIRT3L mitochondrial
, mitochondrial protein lysine deacetylase
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3