anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Antibodies

The protein encoded by SCN4B is one of several sodium channel beta subunits. Additionally we are shipping Sodium Channel, Voltage-Gated, Type IV, beta Subunit Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN4B 6330 Q8IWT1
SCN4B 315611 Q7M730
SCN4B 399548 Q7M729
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Top anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit Antibodies at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of SCN4B expression in U87MG (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2/Jurkat cells, using SCN4B Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SCN4B Antibody [NBP1-86057] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY406238) Immunohistochemistry-Paraffin: SCN4B Antibody [NBP1-86057] - Immunohistochemical staining of human small intestine shows moderate positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275576 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$334.77
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of U-87, using SCN4B antibody. The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 16 Days
$312.70
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SCN4B antibody (ABIN5971181) at 1/1000 dilution. 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit Antibodies

  1. Mammalian Monoclonal SCN4B Primary Antibody for ISt, IHC - ABIN1304847 : Buffington, Rasband: Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)

More Antibodies against Sodium Channel, Voltage-Gated, Type IV, beta Subunit Interaction Partners

Human Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) interaction partners

  1. SCN4B overexpression reduces cancer cell invasiveness and tumour progression.

  2. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.

  3. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys (show DNAJC5 Antibodies) residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion.

  4. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption

  5. Contribution of Cardiac Sodium Channel (show SCN5A Antibodies) beta-Subunit (show POLG Antibodies) Variants to Brugada Syndrome.

  6. Human Nav1.6 (show SCN8A Antibodies) channels generate larger resurgent currents than human Nav1.1 (show SCN1A Antibodies) channels, but the SCN4B-derived Navbeta4 peptide does not protect either isoform from use-dependent reduction.

  7. In a nonreferred nationwide Danish cohort of SIDS (show IDS Antibodies) cases, up to 5/66 (7.5%) of SIDS (show IDS Antibodies) cases can be explained by genetic variants in the sodium channel complex genes.

  8. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene.

  9. SCN5A (show SCN5A Antibodies)-SCN4B were found to be essential for positive selection of CD4 (show CD4 Antibodies)(+) T cells.

  10. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis.

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) interaction partners

  1. Data suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys (show DNAJC5 Antibodies) residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.

  2. Scn4b(-/-) animals have deficits in motor coordination and balance and that firing rates in Scn4b(-/-) Purkinje neurons are markedly attenuated.

  3. NaVbeta4 plays a blocking role that indicates the relative importance of different residues in inducing open-channel block.

  4. Data show that Na(V)beta4 (Scn4b} expression determines multiple aspects of Na channel gating, thereby regulating excitability in cultured cerebellar granule cells.

  5. down-regulation of Scn4b may lead to abnormalities of sodium channel and neurite degeneration in the striatum of Huntington's disease transgenic mice

Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Antigen Profile

Protein Summary

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.

Gene names and symbols associated with SCN4B

  • sodium voltage-gated channel beta subunit 4 (SCN4B) antibody
  • sodium voltage-gated channel beta subunit 4 (Scn4b) antibody
  • sodium channel, type IV, beta (Scn4b) antibody
  • sodium channel, voltage-gated, type IV, beta a (scn4ba) antibody
  • Gm1471 antibody
  • LQT10 antibody
  • Navbeta4 antibody
  • scn4b.1 antibody
  • scn4b1 antibody
  • zgc:165389 antibody

Protein level used designations for SCN4B

sodium channel subunit beta-4 , sodium channel accessory subunit , sodium channel beta 4 subunit , sodium channel, type 4, beta subunit , sodium channel, type IV, beta , sodium channel, type IV, beta polypeptide , voltage gated sodium channel beta 4 subunit , voltage-gated sodium channel beta 4 subunit locus 1 , voltage-gated sodium channel beta4.1 subunit

GENE ID SPECIES
6330 Homo sapiens
315611 Rattus norvegicus
399548 Mus musculus
538100 Bos taurus
566069 Danio rerio
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