anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antibodies

The protein encoded by SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Additionally we are shipping Sodium Channel, Voltage-Gated, Type V, alpha Subunit Proteins (11) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN5A 20271 Q9JJV9
SCN5A 6331 Q14524
SCN5A 25665 P15389
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Top anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SCN5A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Human Muscle WB Suggested Anti-SCN5A Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SCN5A Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  SW620 cell lysate SCN5A is supported by BioGPS gene expression data to be expressed in SW620 Host:  Rabbit  Target Name:  SCN5A  Sample Type:  MCF7 Whole Cell  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  1ug/ml  Peptide Concentration:  5ug/ml  Lysate Quantity:  25ug/lane/Lane  Gel Concentration:  0.12 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-SCN5A Antibody  Catalog Number: ARP34935_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart  Observed Staining: Membrane (stronger than with ARP34934) Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data. WB Suggested Anti-SCN5A Antibody Titration: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey Positive Control: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB Western blot analysis of Nav1.5 expression in mouse cardiac muscle extract ( Lane 1). Nav1.5 at 250KD was detected using rabbit anti-Nav1.5 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$296.69
Details
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.62
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SCN5A antibody ABIN290512 at 5-10 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-SCN5A / Nav1.5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Dog Rabbit Un-conjugated IHC, IHC (p) Anti-SCN5A / Nav1.5 antibody  ABIN1049322 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p) Western Blot: Nav1.5 Antibody [ABIN269816] - Rat Brain lysate . Immunohistochemistry-Paraffin: Nav1.5 Antibody [ABIN269816] - Mouse Brain. 0.1 mg Log in to see 7 to 9 Days
$373.75
Details

Top referenced anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies

  1. Cow (Bovine) Polyclonal SCN5A Primary Antibody for WB - ABIN2776347 : Shah, Wingo, Weiss, Williams, Balser, Chazin: Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal SCN5A Primary Antibody for ELISA, IHC - ABIN269816 : Olson, Michels, Ballew, Reyna, Karst, Herron, Horton, Rodeheffer, Anderson: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. in JAMA 2005 (PubMed)

  3. Cow (Bovine) Polyclonal SCN5A Primary Antibody for IHC, WB - ABIN2776088 : Van Norstrand, Tester, Ackerman: Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. in Heart rhythm : the official journal of the Heart Rhythm Society 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Sodium Channel, Voltage-Gated, Type V, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. The late sodium current inhibitor GS-458967 exhibits anti-arrhythmic potential in cardiac myocytes from Scn5a-1798insD+/- mice.

  2. Our findings indicate that H2O2 inhibits NaV1.5 expression by activating the Wnt/b-catenin signaling and beta-catenin (show CTNNB1 Antibodies) interacts with TCF4 (show TCF4 Antibodies) to transcriptionally suppress cardiac NaV1.5 expression.

  3. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13 (show FGF13 Antibodies)-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

  4. Enhanced A-V conduction in mice overexpressing SCN5A in the heart mimics the human syndrome of Enhanced Atrioventricular Nodal Conduction .

  5. Loss of the C-terminus of connexin43 (show GJA1 Antibodies) limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

  6. Ser571-mediated increases in INa (show INA Antibodies),L promote abnormal repolarization and intracellular Ca(2 (show CA2 Antibodies)+) handling and increase susceptibility to arrhythmia. Ser571 is required for maladaptive remodeling and arrhythmias in response to pressure overload.

  7. intracellular Ca(2 (show CA2 Antibodies)+) contributes to the regulation of INaL conducted by NaV1.5 mutants and propose that, during excitation-contraction coupling, elevated intracellular Ca(2 (show CA2 Antibodies)+) suppresses mutant channel INaL and protects cells from delayed repolarization.

  8. Results show that Nav1.5 upregulation correlates with disease severity in monophasic and chronic-relapsing experimental autoimmune encephalomyelitis and that Nav1.5 expression in astrocytes is modulated in parallel with periods of disease and remission

  9. FoxO1 (show FOXO1 Antibodies) is involved in the modulation of NaV1.5 expression in ischemic heart disease.

  10. Our results suggested that the main expression subtype of sodium channels was Nav1.5 of early embryonic cardiomyocytes.

Human Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. The failing heart has ~30% lower SCN5A levels.

  2. novel variants in SCN5A, KCNH2 (show KCNH2 Antibodies) and KCNQ1 (show KCNQ1 Antibodies) are associated with congenital long QT syndrome in a Polish population

  3. Our study expands the spectrum of SCN5A mutations and contributes to genetic counselling of families with arrhythmia.

  4. Here the authors show that SGK1 (show SGK1 Antibodies) directly regulates NaV1.5 channel function.

  5. The 1795insD mutation in SCN5A reduced the beating rate of the model cell from 74 to 69 beats/min.

  6. Using a human-induced pluripotent stem cells -based model forSCN5A-D1275N-related sodium channelopathy, it was demonstrated that diminished sodium currents resulting from lower NaV1.5 protein levels, which is dependent on proteasomal degradation.

  7. We identified a double heterozygosity for pathogenic mutations in SCN5A and TRPM4 (show TRPM4 Antibodies) in a Brugada syndrome patient.

  8. This SCN5A-p.(Phe1617del) founder population with phenotypic divergence and overlap reveals long-QT syndrome-related and arousal-evoked ventricular tachyarrhythmias with a female preponderance.

  9. The present study revealed that Nav1.5 channels have a more abundant expression in the human brain than previously considered. It also provided further insight into the complexity and functional significance of Nav1.5 channels in human brain neurons.

  10. The H558R polymorphism of the SCN5A gene modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation (show HELLS Antibodies) of SCN5A gene promoters.

Rabbit Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. Freshly dispersed rabbit airway smooth muscle cells express a fast voltage-gated Na(+) current that is mediated mainly by the NaV1.5 subtype.

  2. Mechanisms are determined by a two-dimensional slice model at single-cell and tissue levels in order to determine that SCN5A mutations impair cardiac pacemaking.

Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antigen Profile

Protein Summary

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.

Gene names and symbols associated with SCN5A

  • sodium voltage-gated channel alpha subunit 5 (SCN5A) antibody
  • sodium channel, voltage-gated, type V, alpha (Scn5a) antibody
  • sodium voltage-gated channel alpha subunit 5 (Scn5a) antibody
  • CDCD2 antibody
  • CMD1E antibody
  • CMPD2 antibody
  • HB1 antibody
  • HB2 antibody
  • HBBD antibody
  • HH1 antibody
  • ICCD antibody
  • IVF antibody
  • LQT3 antibody
  • mH1 antibody
  • Nav1.5 antibody
  • Nav1.5c antibody
  • PFHB1 antibody
  • SCAL antibody
  • SkM1 antibody
  • SkM2 antibody
  • SSS1 antibody
  • VF1 antibody

Protein level used designations for SCN5A

sodium channel, voltage-gated, type V, alpha subunit , voltage-gated sodium channel type V alpha , sodium channel protein type 5 subunit alpha , voltage-gated sodium channel cardiac isoform Nav1.5 , sodium channel protein cardiac muscle subunit alpha , sodium channel protein type V subunit alpha , sodium channel voltage-gated type V alpha polypeptide , sodium channel, voltage-gated, type V, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.5 , cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit , cardiac sodium channel , sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) , voltage-gated sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3) , sodium channel, voltage-gated, type 5, alpha subunit , voltage-gated sodium channel Nav1.5c , oltage-gated sodium channel type V alpha , voltage-dependent sodium channel SCN10A , voltage-gated sodium channel H , voltage-gated sodium channel type V alpha polypeptide

GENE ID SPECIES
747523 Pan troglodytes
100034027 Equus caballus
20271 Mus musculus
6331 Homo sapiens
403497 Canis lupus familiaris
282061 Bos taurus
25665 Rattus norvegicus
395947 Gallus gallus
100009516 Oryctolagus cuniculus
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