SCN5A antibody

Catalog No. ABIN7182719

Product Details anti-SCN5A Antibody

Target: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN5A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human sodium channel.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SCN5A

Target: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Alternative Name: SCN5A (SCN5A Products)

Synonyms: Nav1.5 antibody, Nav1.5c antibody, SkM1 antibody, SkM2 antibody, mH1 antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, SSS1 antibody, VF1 antibody, SCAL antibody, sodium voltage-gated channel alpha subunit 5 antibody, sodium channel, voltage-gated, type V, alpha antibody, SCN5A antibody, Scn5a antibody

Background:

Background: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

Sebastian K.G. Maier, Circulation, Mar 2004, 109: 1421 - 1427.
T.R. Cummins, Neurology, Jan 2003, 60: 224 - 229.
Christopher A. Ahern, Circ. Res., May 2005, 96: 991 - 998.
Jyoti Dhar Malhotra, Circulation, Mar 2001, 103: 1303 - 1310.

Aliases: Cardiac tetrodotoxin insensitive voltage dependent sodium channel alpha subunit antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, Scn5a (gene name) antibody, Scn5a antibody, SCN5A_HUMAN antibody, Sodium channel protein cardiac muscle alpha subunit antibody, Sodium channel protein cardiac muscle subunit alpha antibody, Sodium channel protein type 5 subunit alpha antibody, Sodium channel protein type V alpha subunit antibody, Sodium channel protein type V subunit alpha antibody, SSS1 antibody, VF1 antibody, Voltage gated sodium channel alpha subunit Nav1.5 antibody, Voltage-gated sodium channel subunit alpha Nav1.5 antibody

UniProt: Q14524