anti-Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Antibodies

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Additionally we are shipping SLC7A11 Kits (14) and SLC7A11 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Top anti-SLC7A11 Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), SimWes, WB Detection of XCT in total human and mouse stomach lysate, respectively, using ABIN152648.  1 minute ECL exposure. XCT staining in the absorptive epithelia of intestinal villi detected using ABIN152648. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SLC7A11 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190899 (0.02µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: xCT Antibody [ABIN152647] - xCT antibody was tested in HepG2 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated IHC (p) Anti-SLC7A11 antibody  ABIN1049349 IHC staining of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$484.00
Details
Dog Goat Un-conjugated IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$455.40
Details
Human Goat Un-conjugated ELISA, WB Western Blot: SLC7A11 Antibody [ABIN252942] - ABIN252942 (0.02ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: xCT Antibody [ABIN2529425] - Analysis of SLC7A11 using this antibody at 0.02 ug/ml in Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human brain labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details

SLC7A11 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SLC7A11 Antibodies

  1. Human Polyclonal SLC7A11 Primary Antibody for FACS, ICC - ABIN152648 : Liu, Blower, Pham, Fang, Dai, Wise, Green, Teitel, Ning, Ling, Lyn-Cook, Kadlubar, Sadée, Huang: Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. in Molecular pharmacology 2007 (PubMed)
    Show all 38 Pubmed References

  2. Human Polyclonal SLC7A11 Primary Antibody for ICC, IF - ABIN152647 : Pampliega, Domercq, Soria, Villoslada, Rodríguez-Antigüedad, Matute: Increased expression of cystine/glutamate antiporter in multiple sclerosis. in Journal of neuroinflammation 2011 (PubMed)
    Show all 4 Pubmed References

  3. Mouse (Murine) Polyclonal SLC7A11 Primary Antibody for IHC - ABIN967037 : Sato, Tamba, Ishii, Bannai: Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal SLC7A11 Primary Antibody for IHC (p) - ABIN2477153 : Choné, Menges, Wurster: [Leiomyoma of the esophagus with an epiphrenal diverticulum]. in RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1978 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal SLC7A11 Primary Antibody for ELISA, WB - ABIN252942 : Zhang, Trachootham, Liu, Chen, Pelicano, Garcia-Prieto, Lu, Burger, Croce, Plunkett, Keating, Huang: Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. in Nature cell biology 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SLC7A11 Interaction Partners

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. miR (show MLXIP Antibodies)-375 served as a tumor suppressor via regulating SLC7A11.

  2. As targets of oncogenes with intrinsic tyrosine kinase (show TXK Antibodies) activity, STAT3 (show STAT3 Antibodies) and STAT5 (show STAT5A Antibodies) become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT expression. (Review)

  3. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (show NCAPG2 Antibodies)) through TLR2/Akt (show AKT1 Antibodies)- and p38 (show CRK Antibodies)-dependent signaling pathway.

  4. Genetic and pharmacological inhibition of xCT potentiated the cytotoxic effects of aspirin plus sorafenib; this effect was diminished by xCT overexpression. Low-dose aspirin plus sorafenib enhanced the cytotoxicity of cisplatin in resistant HNC (show MMP8 Antibodies) cells through xCT inhibition and oxidant and DNA damage.

  5. MUC1 (show MUC1 Antibodies)-C binds directly with CD44v and in turn promotes stability of xCT in the cell membrane

  6. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR (show C12orf5 Antibodies) and SLC7A11. Moreover, p53 (show TP53 Antibodies)(4KR) is still capable of inducing the p53 (show TP53 Antibodies)-Mdm2 (show MDM2 Antibodies) feedback loop, but p53 (show TP53 Antibodies)-dependent ferroptotic responses are markedly abrogated

  7. ARF inhibits tumor growth by suppressing the ability of NRF2 (show GABPA Antibodies) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 Antibodies) antiporter that regulates reactive oxygen species (ROS (show ROS1 Antibodies))-induced ferroptosis.

  8. Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.

  9. ATF4 (show ATF4 Antibodies) expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4 (show ATF4 Antibodies)-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (show GRIN1 Antibodies) antiporter xCT

  10. Identify mTORC2 (show CRTC2 Antibodies) as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate (show GRIN1 Antibodies) antiporter xCT. mTORC2 (show CRTC2 Antibodies) phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity.

Mouse (Murine) Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (show NCAPG2 Antibodies)) through TLR2/Akt (show AKT1 Antibodies)- and p38 (show CRK Antibodies)-dependent signaling pathway.

  2. Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis.

  3. Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate (show GRIN1 Antibodies) toxicity.

  4. ARF inhibits tumor growth by suppressing the ability of NRF2 (show NFE2L2 Antibodies) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 Antibodies) antiporter that regulates reactive oxygen species (ROS (show ROS1 Antibodies))-induced ferroptosis.

  5. Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.

  6. Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (show GRIN1 Antibodies), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (show GRIN1 Antibodies), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.

  7. HIF-1alpha (show HIF1A Antibodies) plays a role in cerebral ischaemia-reperfusion -induced glutamate (show GRIN1 Antibodies) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (show GRIN1 Antibodies) outflow

  8. Results provided important insights into understanding the mechanism associated with xCT deficiency.

  9. Protein expression of xCT was observed throughout the forebrain and amygdala.

  10. Cerebellar astroglia isolated from Atm (show ATM Antibodies) mutant mice show decreased expression of the cystine/glutamate (show GRIN1 Antibodies) exchanger subunit xCT, glutathione reductase (show GSR Antibodies), and glutathione-S-transferase (show GSTa2 Antibodies)

SLC7A11 Antigen Profile

Protein Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene names and symbols associated with SLC7A11

  • solute carrier family 7 member 11 (SLC7A11) antibody
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) antibody
  • solute carrier family 7 member 11 (Slc7a11) antibody
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) antibody
  • 9930009M05Rik antibody
  • AI451155 antibody
  • CCBR1 antibody
  • DKFZp468E122 antibody
  • SLC7A11 antibody
  • sut antibody
  • xCT antibody

Protein level used designations for SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPECIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
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