anti-Speckle-Type POZ Protein (SPOP-B) Antibodies

In complex with CUL3, involved in ubiquitination and proteasomal degradation of several substrates (By similarity). Additionally we are shipping SPOP-B Kits (28) and SPOP-B Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPOP-B 8405 O43791
SPOP-B 20747 Q6ZWS8
SPOP-B 287643  
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Top anti-SPOP-B Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SPOP Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate SPOP is supported by BioGPS gene expression data to be expressed in HepG2 Host:  Rabbit  Target Name:  SPOP  Sample Tissue:  Human MCF7  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of SPOP expression in HepG2 (A), Hela (B), NIH3T3 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, WB WB Image Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE antibody diluted at 1:2000 WB Image Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Chicken Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated IHC, WB ABIN6272950 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HeLa cells, using SPOP antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated WB Western blot analysis in WiDr cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details

More Antibodies against SPOP-B Interaction Partners

Human Speckle-Type POZ Protein (SPOP-B) interaction partners

  1. results suggested that down-regulation of SPOP promoted osteosarcoma (OS) cells migratory and invasive ability via modulating the "PI3K/Akt/NF-kappaB" signaling pathway; thus, SPOP could be a promising drug target for the treatment of OS invasion

  2. cancer-derived mutations in SPOP or at the Nanog-degron (S68Y) disrupt SPOP-mediated destruction of Nanog, leading to elevated cancer stem cell traits and PrCa progression

  3. An SPOP interactome analysis shows that wild type (WT) SPOP but not mutant SPOP associates with multiple proteins involved in transcription, mRNA splicing and export.

  4. no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models.

  5. LINC01638 interacts with c-Myc to prevent SPOP-mediated c-Myc ubiquitination.

  6. Disease-associated SPOP mutations that lead to the accumulation of proto-oncogenic proteins interfere with phase separation and co-localization in membraneless organelles, suggesting that substrate-directed phase separation of this E3 ligase underlies the regulation of ubiquitin-dependent proteostasis

  7. SPOP inhibits NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity and its target genes expression via FADD in non-small cell lung cancer

  8. TRIM24 and AR coactivated gene signature of SPOP-mutant prostate cancer (PCa) is similarly activated in human PCa with high TRIM28 expression.

  9. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis.

  10. Our result suggests that SPOP expression in blood might have a sensitivity that is low for routine diagnostic use and for screening for Renal cell carcinoma (RCC). However, SPOP could be a potential tissue diagnostic biomarker in RCC.

  11. Expression of the F133V mutation and wild-type SPOP was at much lower levels compared to that of F102C and Y87N mutations; however, at present, it is unknown if this also affects the biological activity of the SPOP protein.

  12. PD-L1 protein abundance is regulated by cyclin D-CDK4 and the cullin 3-SPOP E3 ligase via proteasome-mediated degradation

  13. methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.

  14. these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC expression in prostate physiology, identify c-MYC as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.

  15. Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.

  16. SPOP mutation in endometrial cancer increased degradation of BRD2, BRD3 and BRD4 proteins. SPOP mutation in prostate cancer increased expression of BRD2, BRD3 and BRD4 proteins.

  17. Prostate cancer-derived SPOP mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.

  18. While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.

  19. SPOP mutation activates both PI3K/mTOR and androgen receptor signaling, effectively uncoupling the normal negative feedback between these two pathways.

  20. SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.

Mouse (Murine) Speckle-Type POZ Protein (SPOP-B) interaction partners

  1. SPOP is required for embryo implantation, endometrial decidualization, and uterine health in the mouse

  2. no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models.

  3. loss of Spop, but not Spopl, disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh signaling and skeletal development

  4. Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning.

  5. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.

  6. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  7. miR-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  8. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.

  9. similar S/T-rich motifs are present in Gli proteins as well as in numerous HIB-interacting proteins and mediate Gli degradation by SPOP

  10. MacroH2A1.2 binds the nuclear protein Spop.

  11. Interaction of endogenous PDX-1 and PCIF1 in MIN6 insulinoma cells, is demonstarted.

Xenopus laevis Speckle-Type POZ Protein (SPOP-B) interaction partners

  1. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.

SPOP-B Antigen Profile

Protein Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with SPOP-B

  • speckle type BTB/POZ protein (SPOP) antibody
  • speckle-type POZ protein (Spop) antibody
  • speckle type BTB/POZ protein (Spop) antibody
  • speckle type POZ protein S homeolog (spop.S) antibody
  • AI315626 antibody
  • BTBD32 antibody
  • Pcif1 antibody
  • spop antibody
  • tef2 antibody

Protein level used designations for SPOP-B

HIB homolog 1 , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1 , speckle-type POZ protein B

GENE ID SPECIES
8405 Homo sapiens
20747 Mus musculus
287643 Rattus norvegicus
100173908 Pongo abelii
100343929 Oryctolagus cuniculus
779391 Xenopus laevis
100713182 Cavia porcellus
101111300 Ovis aries
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