SPOP-B antibody (C-Term)

Catalog No. ABIN928333

Product Details anti-SPOP-B Antibody

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Xenopus laevis, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPOP-B antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Frog, Dog (Canine), Chicken, Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: SPOP antibody was raised in rabbit using the C terminal of SPOP as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

SPOP Blocking Peptide, catalog no. 33R-10118, is also available for use as a blocking control in assays to test for specificity of this SPOP antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SPOP-B

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Alternative Name: SPOP (SPOP-B Products)

Synonyms: BTBD32 antibody, TEF2 antibody, AI315626 antibody, Pcif1 antibody, zgc:64140 antibody, spop antibody, tef2 antibody, speckle type BTB/POZ protein antibody, speckle-type POZ protein antibody, speckle type POZ protein S homeolog antibody, SPOP antibody, Spop antibody, spop antibody, spop.S antibody

Background: SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Synonyms: Polyclonal SPOP antibody, Anti-SPOP antibody, speckle-type POZ protein antibody, TEF2 antibody.