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Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. Additionally we are shipping SHB Antibodies (61) and many more products for this protein.
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Shb binds to tyrosine 1175 in the VEGFR-2 (show KDR Proteins), which regulates VEGF (show VEGFA Proteins)-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner [shb]
This article provides a resource for the available molecular tools that can be used in future research on Shb
It is concluded that tumor SHB gene expression relates to acute myeloid leukemia (show BCL11A Proteins) survival
SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review]
SH2-Bbeta is a Rac (show AKT1 Proteins)-binding protein that regulates cell motility
Shb links SLP-76 (show LCP2 Proteins) and Vav (show VAV1 Proteins) with the CD3 (show CD3 Proteins) complex in Jurkat T cells (SLP-76 (show LCP2 Proteins))
SHB links IL2 (show IL2 Proteins) receptor for signal transduction and mediates apoptosis
Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF-induced neurite outgrowth.
It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 (show PDX1 Proteins) and insulin (show INS Proteins) in EBs and that such cells can be separated by FACS.
The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow
a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8 (show CD8A Proteins)+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas.
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood.
loss of Shb alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy
Shb knockout mouse exhibited structural and functional (angiogenesis and vascular permeability) vascular abnormalities that have implications for understanding the function of VEGF-A (show VEGFA Proteins) under physiological conditions
Data show reduced VEGF-A (show VEGFA Proteins) expression in Shb-deficient tumors.Interference with Shb signaling may provide novel means for future cancer therapy.
Shb appears to play an important modulating role on T- Cell receptor signaling, thus regulating the peripheral CD4 (show CD4 Proteins)+ T(H)2 cell response.
It is concluded that SHB regulates normal oocyte and follicle development and that perturbation of SHB signaling causes defective meiosis I and early embryo development
Shb binds directly to FAK (show PTK2 Proteins) and regulates its phosphorylation leading to enhanced cell spreading in a Src (show SRC Proteins)-dependent manner.
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Src homology 2 domain containing adaptor protein B
, SH2 domain-containing adapter protein B-like
, SH2 domain-containing adapter protein B
, SHB (Src homology 2 domain containing) adaptor protein B
, SHB adaptor protein (a Src homology 2 protein)