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TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.
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Human Polyclonal TYROBP Primary Antibody for IHC, IHC (p) - ABIN4304256
Preusse, Goebel, Pehl, Rinnenthal, Kley, Allenbach, Heppner, Vorgerd, Authier, Gherardi, Stenzel: Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis. in Neuropathology and applied neurobiology 2015
The structure of the adaptor protein dap12 has been identified in the zebrafish genome.
DAP12-based activating pathway is conserved between bony fish and mammals
Mutations in TYROBP are not a common cause of dementia in this Turkish cohort.
Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 (show TREM2 Antibodies) expression, a well-established risk factor for AD.
TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 (show ZNF329 Antibodies) and RB1 (show RB1 Antibodies) significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.
TYROBP/CSTA (show CSTA Antibodies) gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis
The different expression of DAP12 compared to TREM2 (show TREM2 Antibodies) represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.
the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1 (show CSF1 Antibodies)-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation
Impaired signaling by the TREM2 (show TREM2 Antibodies)-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.
T cells modified to express a KIR (show GEM Antibodies)-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta (show CD247 Antibodies)-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.
This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.
isolated PMNs have an increased proportion of both TREM1 (show TREM1 Antibodies) and DAP12 compared to normal healthy control
We identified modulatory effects of TYROBP deficiency on the level of phosphorylation of TAU that was accompanied by a reduction in the severity of neuritic dystrophy. TYROBP deficiency also altered the expression of several AD related genes, including Cd33 (show CD33 Antibodies). Electrophysiological abnormalities and learning behavior deficits associated with APP (show APP Antibodies)/PSEN1 (show PSEN1 Antibodies) transgenes were greatly attenuated on a Tyrobp-null background.
These results demonstrate that PTX targets the innate immunity through DAP12, FcRgamma, and MyD88 providing new insights into the immunobiology of PTX.
Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 (show TREM2 Antibodies) and DAP12, both of which are expressed by microglia and have bee
TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Antibodies), DNAX-activation protein 12, and cell proliferation.
The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.
significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration
DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death
results support a role of DAP12 in stabilizing TREM2 (show TREM2 Antibodies)-CTF (show NFIA Antibodies), thereby protecting against excessive pro-inflammatory responses.
a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.
DAP12 expression in liver grafts regulates donor mDC (show ADAM11 Antibodies) migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
TYRO protein tyrosine kinase-binding protein
, TYRO protein tyrosine kinase binding protein
, DAP12 protein
, DNAX-activation protein 12
, killer cell activating receptor-associated protein
, KAR-associated protein
, killer activating receptor associated protein
, killer-activating receptor-associated protein
, killer cell activating receptor associated protein
, immunoreceptor DAP12
, tyrosine kinase binding protein