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The protein encoded by TSPAN8 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
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overexpression of tm4sf3 promoted development of annular pancreas.
these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin (show CDH1 Proteins), EGFR (show EGFR Proteins) and CD44 (show CD44 Proteins) appear as likely candidates.
Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder.
Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression
LCMR1 (show MED19 Proteins) modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo.
Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK (show ILK Proteins)) axis and establish Tspan8 as a negative regulator of ILK (show ILK Proteins) activity.
TSPAN8 might be important for the orchestration of meprin beta (show MEP1B Proteins) at the cell surface with impact on certain proteolytic processes
Knocking down TSPAN8 in AEG-1 (show MTDH Proteins)-overexpressing human hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1 (show MTDH Proteins)-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice
Knockdown and knockout models revealed that CD151 (show CD151 Proteins) and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review]
Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation.
TSPAN8 is involved in tumor progression and is an independent prognostic classifier in patients with gastric cancer.
Transplantation studies provided definitive evidence that a TSPAN8-high subpopulation is enriched for spermatogonial stem cells.
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
, transmembrane 4 superfamily member 3
, tumor-associated antigen CO-029