Tight Junction Protein 2 (Zona Occludens 2) Proteins (TJP2)

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Additionally we are shipping TJP2 Antibodies (111) and TJP2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TJP2 9414 Q9UDY2
Mouse TJP2 TJP2 21873 Q9Z0U1
Rat TJP2 TJP2 115769  
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Top TJP2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$672.00
Details

TJP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaction Partners

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Biochemistry and microscopy approaches in T cells confirmed SNX27 (show SNX27 Proteins)/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

  2. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 (show VIPAR Proteins)

  3. Patients with a confirmed ABCB11 (show ABCB11 Proteins) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (show ATP8B1 Proteins) mutation had an elevated THBA proportion (7.51-37.26%).

  4. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  5. Data identified two Disease-causing Genes TJP2 and GJB2 (show GJB2 Proteins) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  6. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  7. Claudin-19 (show CLDN19 Proteins), the most abundant claudin in myelin, exhibited no binding to ZO2.

  8. JAM-A (show F11R Proteins) regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 (show RAPGEF2 Proteins) to activate Rap2c (show RAP2C Proteins) and control contraction of the apical cytoskeleton.

  9. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  10. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (show MMP14 Proteins)

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 (show TJP1 Proteins) and ZO-2 genes accelerated the defects observed in ZO-1 (show TJP1 Proteins) knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1 (show TJP1 Proteins)-dependent regulation of podocyte filtration barrier.

  2. In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein (show OCLN Proteins), decreased in the bladder of OVX mice indicating a possible role in overactive bladder.

  3. Expression of Podocalyxin (show PODXL Proteins), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (show TJP1 Proteins) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (show EZR Proteins).

  4. SNX27 (show SNX27 Proteins) associates with ZO-2 and modulates the epithelial tight junction.

  5. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

  6. the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent

  7. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  8. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  9. ZO-1 (show TJP1 Proteins) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  10. These findings indicate that ZO-1 (show TJP1 Proteins) and ZO-2 can independently determine whether and where claudins are polymerized.

Zebrafish Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. analysis of tissue distribution and developmental expression of tjp1/zo-1 (show TJP1 Proteins), tjp2/zo-2 and tjp3/zo-3 (show TJP3 Proteins) in the zebrafish, Danio rerio

TJP2 Protein Profile

Protein Summary

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with TJP2

  • tight junction protein 2 (TJP2)
  • tight junction protein 2 (Tjp2)
  • tight junction protein 2 L homeolog (tjp2.L)
  • tight junction protein 2b (zona occludens 2) (tjp2b)
  • C9DUPq21.11 protein
  • DFNA51 protein
  • DUP9q21.11 protein
  • tjp2 protein
  • wu:fb62b09 protein
  • x104 protein
  • zgc:92094 protein
  • zo-2 protein
  • zo2 protein

Protein level used designations for TJP2

Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , tight junction protein 2 (zona occludens 2) , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2 , tight junction protein 2 L homeolog , fb62b09 , tight junction protein 2b , tjp2.2 , zo-2.2

GENE ID SPECIES
9414 Homo sapiens
100229218 Taeniopygia guttata
21873 Mus musculus
115769 Rattus norvegicus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
100729549 Cavia porcellus
779228 Xenopus laevis
436639 Danio rerio
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