Tight Junction Protein 2 (Zona Occludens 2) Proteins (TJP2)

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

1. Biochemistry and microscopy approaches in T cells confirmed SNX27 (show SNX27 Proteins)/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

2. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 (show VIPAR Proteins)

3. Patients with a confirmed ABCB11 (show ABCB11 Proteins) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (show ATP8B1 Proteins) mutation had an elevated THBA proportion (7.51-37.26%).

4. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

5. Data identified two Disease-causing Genes TJP2 and GJB2 (show GJB2 Proteins) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

6. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

7. Claudin-19 (show CLDN19 Proteins), the most abundant claudin in myelin, exhibited no binding to ZO2.

8. JAM-A (show F11R Proteins) regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 (show RAPGEF2 Proteins) to activate Rap2c (show RAP2C Proteins) and control contraction of the apical cytoskeleton.

9. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

10. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (show MMP14 Proteins)

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

1. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 (show TJP1 Proteins) and ZO-2 genes accelerated the defects observed in ZO-1 (show TJP1 Proteins) knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1 (show TJP1 Proteins)-dependent regulation of podocyte filtration barrier.

2. In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein (show OCLN Proteins), decreased in the bladder of OVX mice indicating a possible role in overactive bladder.

3. Expression of Podocalyxin (show PODXL Proteins), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (show TJP1 Proteins) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (show EZR Proteins).

4. SNX27 (show SNX27 Proteins) associates with ZO-2 and modulates the epithelial tight junction.

5. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

6. the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent

7. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

8. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

9. ZO-1 (show TJP1 Proteins) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

10. These findings indicate that ZO-1 (show TJP1 Proteins) and ZO-2 can independently determine whether and where claudins are polymerized.

Zebrafish Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

1. analysis of tissue distribution and developmental expression of tjp1/zo-1 (show TJP1 Proteins), tjp2/zo-2 and tjp3/zo-3 (show TJP3 Proteins) in the zebrafish, Danio rerio