Tight Junction Protein 2 (Zona Occludens 2) Proteins (TJP2)

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Additionally we are shipping TJP2 Antibodies (120) and TJP2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TJP2 9414 Q9UDY2
Mouse TJP2 TJP2 21873 Q9Z0U1
Rat TJP2 TJP2 115769  
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Top TJP2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg 15 to 18 Days
$672.00
Details

TJP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaction Partners

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration.

  2. Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status.

  3. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

  4. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39

  5. Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 mutation had an elevated THBA proportion (7.51-37.26%).

  6. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  7. Data identified two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  8. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  9. Claudin-19, the most abundant claudin in myelin, exhibited no binding to ZO2.

  10. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton.

  11. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  12. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP

  13. the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.

  14. ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.

  15. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP.

  16. these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 and uPAR in VSMC intercellular communications.

  17. ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; YAP2/ZO-2 complex appears to be involved in cell detachment

  18. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds.

  19. the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ

  20. TJP2- and GSK-3beta-mediated increased susceptibility to apoptosis of cells of the inner ear is the mechanism for adult-onset hearing loss in this kindred and may serve as one model for age-related hearing loss in the general population.

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue.

  2. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier.

  3. In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein, decreased in the bladder of OVX mice indicating a possible role in overactive bladder.

  4. Expression of Podocalyxin, which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin.

  5. SNX27 associates with ZO-2 and modulates the epithelial tight junction.

  6. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt/beta-catenin signaling pathway

  7. the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent

  8. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  9. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  10. ZO-1 and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  11. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized.

  12. These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation.

  13. Early embryonic lethality of mice lacking Tjp2, but not Tjp3, reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

  14. analysis of ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula

  15. Quantitative analysis of trophectoderm tight junctions in ZO-2-deficient embryos revealed increased assembly of ZO-1 but not occludin, indicating ZO protein redundancy as a compensatory mechanism contributing to the mild phenotype observed.

  16. ZO-2 play pivotal roles in the final establishment of the belt-like adherens junctions (zonula adherens), followed by the formation of the belt-like TJs (zonula occludens) with paracellular barrier function

Zebrafish Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. analysis of tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio

TJP2 Protein Profile

Protein Summary

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with TJP2

  • tight junction protein 2 (TJP2)
  • tight junction protein 2 (Tjp2)
  • tight junction protein 2 L homeolog (tjp2.L)
  • tight junction protein 2b (zona occludens 2) (tjp2b)
  • C9DUPq21.11 protein
  • DFNA51 protein
  • DUP9q21.11 protein
  • tjp2 protein
  • wu:fb62b09 protein
  • x104 protein
  • zgc:92094 protein
  • zo-2 protein
  • zo2 protein

Protein level used designations for TJP2

Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , tight junction protein 2 (zona occludens 2) , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2 , tight junction protein 2 L homeolog , fb62b09 , tight junction protein 2b , tjp2.2 , zo-2.2

GENE ID SPECIES
9414 Homo sapiens
100229218 Taeniopygia guttata
21873 Mus musculus
115769 Rattus norvegicus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
100729549 Cavia porcellus
779228 Xenopus laevis
436639 Danio rerio
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