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TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Additionally we are shipping TRPM6 Kits (8) and TRPM6 Proteins (5) and many more products for this protein.
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Knockout of TRPM6 or inactivation of its kinase results in global changes in histone S/T phosphorylation and changes the transcription of hundreds of genes.
Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia.
TNF-alpha (show TNF Antibodies) rescues the EGFR (show EGFR Antibodies) tyrosine kinase (show TXK Antibodies) inhibitor-induced decrease in TRPM6 expression and Mg2 (show MUC7 Antibodies)+ influx mediated via the activation of an NF-kappaB (show NFKB1 Antibodies) signaling pathway.
A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia.
Data show that resistant cells express lower amounts of the transient receptor potential cation channel (show TRPV1 Antibodies) subfamily M TRPM6 and 7, both involved in magnesium transport.
The Different Roles of The Channel-Kinases TRPM6 and TRPM7 (show TRPM7 Antibodies)
we showed that two serum magnesium associated loci, MUC1 (show MUC1 Antibodies) and TRPM6, had significant effect modification with progestin use and insulin (show INS Antibodies) levels, respectively, in European Americans.
N-Myc (show MYCN Antibodies) can promote neuroblastoma (show ARHGEF16 Antibodies) cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 (show TRPM7 Antibodies)
TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.
Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance.
Hence, maintenance of organismal Mg(2 (show MCOLN1 Antibodies)+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.
TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2 (show CA2 Antibodies)+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7 (show TRPM7 Antibodies)-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.
in a model of inherited hypomagnesemia, TRPM6 and TRPM7 (show TRPM7 Antibodies), but not paracellin-1 (show CLDN16 Antibodies), are downregulated
TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
MsrB1 (show SEPX1 Antibodies) recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
In C57BL/6J mice, dietary Mg(2 (show MCOLN1 Antibodies)+)-restriction results in increased Mg(2 (show MCOLN1 Antibodies)+) (re)absorption, which is correlated with increased TRPM6 expression.
REA (show PHB2 Antibodies) operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2 (show MCOLN1 Antibodies)+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2 (show MCOLN1 Antibodies)+) transport.
Modulation of TRPM6 and Na(+)/Mg(2 (show MCOLN1 Antibodies)+) exchange in mammary epithelial cells in response to variations of magnesium availability.
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
transient receptor potential cation channel, subfamily M, member 6
, channel kinase 2
, melastatin-related TRP cation channel 6
, transient receptor potential cation channel subfamily M member 6
, transient receptor potential cation channel 6/channel-kinase 2