anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) Antibodies

TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Additionally we are shipping TRPM6 Kits (8) and TRPM6 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRPM6 140803 Q9BX84
TRPM6 225997 Q8CIR4
TRPM6 293874  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-TRPM6 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB CHAK2 Antibody (H332) (ABIN392616) western blot analysis in CEM cell line lysates (35 µg/lane).This demonstrates the CHAK2 antibody detected the CHAK2 protein (arrow). TRPM6(CHAK2) Antibody (Center) (ABIN392616)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in CEM cell line lysates (35ug/lane). TRPM6(CHAK2) Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRPM6 Antibody (CHAK2) for immunohistochemistry. 400 μL Log in to see 2 to 3 Days
$515.63
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, ELISA, WB TRPM6 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue. TRPM6 antibody western blot analysis in CEM lysate 0.4 mL Log in to see 2 to 3 Days
$452.38
Details
Human Rabbit PE IHC, ELISA   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit APC IHC, ELISA   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit Biotin IHC, ELISA   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit FITC IHC, ELISA   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Rat Rabbit Un-conjugated IHC   100 μL Log in to see 7 to 8 Days
$454.67
Details

Top referenced anti-TRPM6 Antibodies

  1. Human Polyclonal TRPM6 Primary Antibody for IHC (p), ELISA - ABIN544210 : Jhiang: The RET proto-oncogene in human cancers. in Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TRPM6 Primary Antibody for IHC (p), WB - ABIN392616 : Ikari, Okude, Sawada, Takahashi, Sugatani, Miwa: Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A. in Naunyn-Schmiedeberg's archives of pharmacology 2008 (PubMed)
    Show all 3 Pubmed References

  3. Polyclonal TRPM6 Primary Antibody for IF, IHC - ABIN2801829 : Lee, Chen, Ng, Lai, Lien: Renal adaptation to gentamicin-induced mineral loss. in American journal of nephrology 2012 (PubMed)

More Antibodies against TRPM6 Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) interaction partners

  1. Results identified high expression of TRPM6 to be indicative of a prolonged overall survival in colorectal patients. Computational analysis suggest that TRPM6 may be targeted by hsalet7g and hsalet7f1.

  2. Spectrometric analysis identified phosphorylation sites in TRPM6 protein.

  3. These findings confirm that TRPM6 cannot be replaced by TRPM7, and that TRPM6/7 complexes and TRPM6/7-mediated Mg(2+) influx are indispensable in human epithelial colon cells.

  4. Knockout of TRPM6 or inactivation of its kinase results in global changes in histone S/T phosphorylation and changes the transcription of hundreds of genes.

  5. Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia.

  6. TNF-alpha rescues the EGFR tyrosine kinase inhibitor-induced decrease in TRPM6 expression and Mg2+ influx mediated via the activation of an NF-kappaB signaling pathway.

  7. A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia.

  8. Data show that resistant cells express lower amounts of the transient receptor potential cation channel subfamily M TRPM6 and 7, both involved in magnesium transport.

  9. The Different Roles of The Channel-Kinases TRPM6 and TRPM7

  10. we showed that two serum magnesium associated loci, MUC1 and TRPM6, had significant effect modification with progestin use and insulin levels, respectively, in European Americans.

  11. N-Myc can promote neuroblastoma cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7

  12. TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.

  13. Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance.

  14. Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 influences the biological activity of the ion channels.

  15. We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2+) (re)absorption as a consequence of loss of TRPM6 channel function.

  16. TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain.

  17. TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7.M6 channel complex.

  18. Two novel mutations in Chinese sisters with familial hypomagnesemia with secondary hypocalcemia were found: one frameshift mutation (c.1196delC) and one non-sense mutation (c.4577G>A). Both patients were compound heterozygotes for these mutations.

  19. PIP2 is required for TRPM6 channel function; hydrolysis of PIP2 by PLC-coupled hormones/agonists may constitute an important pathway for TRPM6 gating, and perhaps Mg2+ homeostasis.

  20. Case Report: Resolving basal ganglia calcification in hereditary hypomagnesemia with secondary hypocalcemia due to a novel TRPM6 gene mutation.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) interaction partners

  1. Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.

  2. TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.

  3. in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated

  4. TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia

  5. consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.

  6. MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.

  7. Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.

  8. In C57BL/6J mice, dietary Mg(2+)-restriction results in increased Mg(2+) (re)absorption, which is correlated with increased TRPM6 expression.

  9. REA operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2+) transport.

  10. Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability.

TRPM6 Antigen Profile

Protein Summary

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with TRPM6

  • transient receptor potential cation channel subfamily M member 6 (TRPM6) antibody
  • transient receptor potential cation channel, subfamily M, member 6 (Trpm6) antibody
  • CHAK2 antibody
  • HMGX antibody
  • HOMG antibody
  • HOMG1 antibody
  • HSH antibody
  • TRPM6 antibody
  • TRPM6/CHAK2 antibody

Protein level used designations for TRPM6

transient receptor potential cation channel, subfamily M, member 6 , channel kinase 2 , melastatin-related TRP cation channel 6 , transient receptor potential cation channel subfamily M member 6 , transient receptor potential cation channel 6/channel-kinase 2

GENE ID SPECIES
527597 Bos taurus
472957 Pan troglodytes
484163 Canis lupus familiaris
706119 Macaca mulatta
140803 Homo sapiens
225997 Mus musculus
293874 Rattus norvegicus
Selected quality suppliers for anti-TRPM6 (TRPM6) Antibodies
Did you look for something else?