TRPM6 antibody (AA 317-348)

Catalog No. ABIN392616

Cited in 3+ publications. The Rabbit Polyclonal anti-TRPM6 antibody (Clone RB3407) (ABIN392616) specifically detects TRPM6 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for TRPM6 antibody (AA 317-348) (ABIN392616)

Target: TRPM6 (Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPM6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3407

Product Details anti-TRPM6 Antibody

Binding Specificity: AA 317-348

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TRPM6 (CHAK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-348 amino acids from the Central region of human TRPM6 (CHAK2).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-TRPM6 antibody (ABIN392616)

Furukawa, Fujii, Manabe, Matsunaga, Endo, Hasegawa, Ito, Yamaguchi, Yamazaki, Ikari: "Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor." in: Journal of cellular physiology, Vol. 232, Issue 10, pp. 2841-2850, (2017) (PubMed).

Ikari, Okude, Sawada, Takahashi, Sugatani, Miwa: "Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 377, Issue 4-6, pp. 333-43, (2008) (PubMed).

Ikari, Okude, Sawada, Yamazaki, Sugatani, Miwa: "TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells." in: Biochemical and biophysical research communications, Vol. 369, Issue 4, pp. 1129-33, (2008) (PubMed).

Target Details for TRPM6

Target: TRPM6 (Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6))

Alternative Name: TRPM6 (CHAK2)

Background: CHAK2 is a member of the ion channel proteins. It regulates the calcium concentration in cells, which is imperative for such functions as muscle contractions and neuronal firing. It is also upregulated in certain forms of cancer and could play a role in diabetes.

Molecular Weight: 231708

Gene ID: 140803

NCBI Accession: NP_001170781, NP_001170782, NP_060132

UniProt: Q9BX84