Transmembrane Protease, serine 2 Proteins (TMPRSS2)

TMPRSS2 encodes a protein that belongs to the serine protease family. Additionally we are shipping TMPRSS2 Antibodies (73) and TMPRSS2 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMPRSS2 7113 O15393
Rat TMPRSS2 TMPRSS2 156435  
TMPRSS2 50528 Q9JIQ8
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Top TMPRSS2 Proteins at

Showing 7 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

TMPRSS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
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More Proteins for Transmembrane Protease, serine 2 (TMPRSS2) Interaction Partners

Human Transmembrane Protease, serine 2 (TMPRSS2) interaction partners

  1. Our findings indicate that TGF-beta (show TGFB1 Proteins) signaling is a major determinant of EMT (show ITK Proteins) in T/E overexpressing LNCaP cells.

  2. A potential novel function of TMPRSS2-ERG (show ERG Proteins) as a major regulator of IGF1R (show IGF1R Proteins) gene expression.

  3. Study shows that T2E fusion transcripts are associated with higher levels of AMACR (show AMACR Proteins) mRNA in patients with atypical small acinar proliferation (ASAP (show MAP9 Proteins)) which represents an indicator of risk for prostate cancer in patients with ASAP (show MAP9 Proteins).

  4. TMPRSS2-ERG (show ERG Proteins) may have a role in progression of prostate neoplasms and in alteration of the metabolic profile

  5. Meta-analysis showed the prevalence of TMPRSS2:ERG (show ERG Proteins) fusions in prostate cancer to be highest in men of European descent (49%), followed by Asians (27%) and then African (25%) descent.

  6. Data show that tumors displaying TMPRSS2-ERG (show ERG Proteins) fusions that retained interstitial genes were less likely to be associated with biochemical recurrence

  7. We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2-ERG (show ERG Proteins) gene fusions. The transcriptional status and epigenetic features of the target genes influence this effect.

  8. NOTCH (show NOTCH1 Proteins) pathway inhibition antagonizes the growth and invasion of transmembrane protease serine 2 (TMPRSS2)-transforming protein ERG (ERG) (T2E) -positive prostate cancer cells.

  9. The TMPRSS2-ERG (show ERG Proteins) gene fusion is the most frequently observed genetic aberration in prostate cancer.

  10. Study provide evidence that PTEN deletion and TMPRSS2-ERG (show ERG Proteins) gene fusion were mutually exclusive in patients with prostate neoplasm. TMPRSS2-ERG (show ERG Proteins) gene fusion was rare compared to peripheral zone tumors and to PTEN inactivation in T1a (show PDPN Proteins) transition zone tumors.

Mouse (Murine) Transmembrane Protease, serine 2 (TMPRSS2) interaction partners

  1. Study shows that Influenza A (IAV) possessing a monobasic cleavage site in the haemagglutinin (HA) replicates poorly in TMPRSS2 knockout mice due to insufficient HA cleavage. On the contrary, IBV successfully underwent HA cleavage in TMPRSS2 knockout mice, and that the mouse-adapted strain was fully pathogenic. These data demonstrate a clear difference between IAV and IBV in their molecular mechanisms for spreading.

  2. DPP4 (show DPP4 Proteins):CD9 (show CD9 Proteins):TTSP (show TMPRSS11E Proteins) as the protein complexes are necessary for early efficient MERS-coronavirus entry.

  3. Genetic inhibition of TMPRSS2-ERG (show ERG Proteins) junction oncogene (show RAB1A Proteins) in prostate cancer by means of siRNA has strong antineoplastic effect in a mouse model and in vitro.

  4. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis

  5. TMPRSS2 as a host cell factor essential for viral spread and pathogenesis of mono-basic H1N1 and H3N2 influenza A viruses.

  6. These results demonstrate that TMPRSS2 expression is essential for influenza A virus replication in vivo.

  7. These data demonstrate that TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 and H1N1 influenza virus in mice.

  8. Loss of TMPRSS2 serine protease (show F2 Proteins) activity does not influence fertility, reduce survival, result in prostate hyperplasia or carcinoma, or alter prostatic luminal epithelial cell regrowth following castration and androgen replacement.

TMPRSS2 Protein Profile

Protein Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TMPRSS2

  • transmembrane protease serine 2-like (LOC100739411)
  • transmembrane protease, serine 2 (TMPRSS2)
  • transmembrane protease, serine 2 (Tmprss2)
  • D16Ertd61e protein
  • PP9284 protein
  • PRSS10 protein

Protein level used designations for TMPRSS2

epitheliasin , serine protease 10 , transmembrane protease serine 2 , plasmic transmembrane protein X

100739411 Sus scrofa
7113 Homo sapiens
156435 Rattus norvegicus
50528 Mus musculus
418528 Gallus gallus
100732077 Cavia porcellus
100337870 Oryctolagus cuniculus
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