anti-Tryptophan 2,3-Dioxygenase (TDO2) Antibodies

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Additionally we are shipping Tryptophan 2,3-Dioxygenase Kits (21) and Tryptophan 2,3-Dioxygenase Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TDO2 6999 P48775
TDO2 56720 P48776
TDO2 64206 P21643
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Top anti-Tryptophan 2,3-Dioxygenase Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-TDO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TDO2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Small Intestine Host:  Rabbit  Target Name:  TDO2  Sample Tissue:  Human Liver Tumor  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged TDO2 is approximately 10ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB TDO2 Antibody (N-term) (ABIN658265) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the TDO2 antibody detected the TDO2 protein (arrow). Anti-TDO2 Antibody (N-term) at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2. Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TDO2 mouse monoclonal antibody. (ABIN2455754) 0.1 mL Log in to see 2 to 3 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details

Top referenced anti-Tryptophan 2,3-Dioxygenase Antibodies

  1. Human Polyclonal TDO2 Primary Antibody for WB - ABIN948536 : Xiao, Li, Jones-Brando, Yolken: Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strains. in Journal of neural transmission (Vienna, Austria : 1996) 2013 (PubMed)

  2. Human Polyclonal TDO2 Primary Antibody for WB - ABIN520811 : Ohira, Hagihara, Toyama, Takao, Kanai, Funakoshi, Nakamura, Miyakawa: Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus. in Molecular brain 2010 (PubMed)

More Antibodies against Tryptophan 2,3-Dioxygenase Interaction Partners

Human Tryptophan 2,3-Dioxygenase (TDO2) interaction partners

  1. TDO2 overexpression was related to poor prognosis and associated with cancer cell proliferation and tumor stem cells in esophageal squamous cell carcinoma.

  2. Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation.

  3. the potent antimicrobial as well as immunoregulatory effects of TDO were substantially impaired under hypoxic conditions that pathophysiologically occur in vivo. This might be detrimental for the appropriate host immune response towards relevant pathogens.

  4. High TDO2 expression is associated with Colorectal Cancer.

  5. Crystal tryptophan 2,3-dioxygenase structure revealed eight residues playing critical roles in L-tryptophan oxidation.

  6. IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis.

  7. Identification of 12 polymorphisms in the human TDO2 promoter region, 2 of them corresponding to previously unknown single-nucleotide polymorphisms and 3 of them located in putative glucocorticoid-responsive elements.

  8. TDO is highly expressed in the brains of Alzheimer disease patients.

  9. Data suggest that T342 in hTDO has critical role in controlling substrate binding, substrate stereoselectivity, H-bonding interaction between enzyme and intermediates, and regulating the dynamics of protein structure.

  10. The data suggest that TDO uses a ring-opening mechanism during N-formylkynurenine formation, rather than Criegee or dioxetane mechanisms as previously proposed.

  11. Studies indicate that the heme dioxygenases are differentiated by their ability to catalyze the oxidation of l-tryptophan to N-formylkynurenine.

  12. subtle differences between the TDO and IDO reactions

  13. The activity and mRNA expression level of indoleamine 2,3-dioxygenase in term placentas were significantly lower in preeclampsia. Could cause dysregulation of inflammatory response intrinsic to normal pregnancy.

  14. Polymorphism of tryptophan 2,3 dioxygenase gene is associated with autism.

  15. We found that astrocytes, neurons, and microglia expressed IDO but only microglia were able to produce detectable amounts of quinolinic acid. However, astrocytes and neurons had the ability to catabolize quinolinic acid.

  16. significant mechanistic differences exist across the heme dioxygenase family, and the data are discussed within this broader framework

  17. The tyrosine 42 of recombinant human TDO is responsible for the cooperative binding of l-Trp by participating in the active site of the adjacent subunit.

  18. TDO mediates antimicrobial and immunoregulatory effects. TDO-dependent inhibition of T-cell growth might be involved in the immunotolerance observed in vivo during allogeneic liver transplantation.

Mouse (Murine) Tryptophan 2,3-Dioxygenase (TDO2) interaction partners

  1. TDO-deficiency protected from neuronal loss in the spinal cord but not in the optic nerves.

  2. Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation.

  3. Data suggest that Indoleamine 2,3-dioxygenase 1 (IDO1) appears to be a potential hallmark of liver lesions, and its deficiency protects mice from CCl4-induced fibrosis mediated by Th17 cells down-regulation and tryptophan 2,3-dioxygenase (TDO) compensatory increase.

  4. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.

  5. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt = nicotinamide N-methyltransferase)

  6. both TDO and IDO biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice

  7. Data indicate that tryptophan 2,3-dioxygenase (Tdo2) may play an important role during mouse decidualization and be regulated by estrogen, progesterone, and cAMP.

  8. These findings demonstrate a direct molecular link between Trp metabolism and neurogenesis and anxiety-related behavior under physiological conditions.

  9. Endometrial expression of TDO in epithelial and stromal cells is regulated by HOXA10. Expression level of TDO influences infiltration of T-cells into endometrial stroma and thus may influence embryo viability.

  10. These findings indicate that TDO might be required at a late-stage of granule cell development, such as during axonal and dendritic growth, synaptogenesis and its maturation.

  11. No relationship was found between alcohol consumption, Tdo2 activity, and single nucleotide substitution in intron 6 of the Tdo2 gene assoiated with predisposition to alcoholism in humans.

  12. Our findings indicate that TDO and its novel variants may play an important role in not only the liver but also in local areas in developing and adult brain.

Tryptophan 2,3-Dioxygenase (TDO2) Antigen Profile

Protein Summary

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene names and symbols associated with TDO2

  • tryptophan 2,3-dioxygenase b (tdo2b) antibody
  • tryptophan 2,3-dioxygenase (tdo2) antibody
  • tryptophan 2,3-dioxygenase (TDO2) antibody
  • tryptophan 2,3-dioxygenase (MADE_02822) antibody
  • tryptophan 2,3-dioxygenase (CtCNB1_3657) antibody
  • tryptophan 2,3-dioxygenase a (tdo2a) antibody
  • tryptophan 2,3-dioxygenase (CNC04830) antibody
  • tryptophan 2,3-dioxygenase (tdo) antibody
  • tryptophan 2,3-dioxygenase (Mrub_2119) antibody
  • tryptophan 2,3-dioxygenase (Deipr_2235) antibody
  • tryptophan 2,3-dioxygenase (Acav_1166) antibody
  • tryptophan 2,3-dioxygenase (Mesop_4278) antibody
  • tryptophan 2,3-dioxygenase (Tdo2) antibody
  • tryptophan 2,3-dioxygenase L homeolog (tdo2.L) antibody
  • AA407491 antibody
  • chky antibody
  • DDBDRAFT_0190495 antibody
  • DDBDRAFT_0231363 antibody
  • DDB_0190495 antibody
  • DDB_0231363 antibody
  • fb62b10 antibody
  • fi30d08 antibody
  • Tdo antibody
  • tdo2 antibody
  • tdo2l antibody
  • TO antibody
  • TPH2 antibody
  • TRPO antibody
  • wu:fb62b10 antibody
  • wu:fi30d08 antibody
  • zgc:63488 antibody
  • zgc:103693 antibody

Protein level used designations for TDO2

TDO-B , TO-B , TRPO-B , tryptamin 2,3-dioxygenase B , tryptophan 2,3-dioxygenase B , tryptophan 2,3-dioxygenase, like , tryptophan oxygenase B , tryptophan pyrrolase B , tryptophanase B , TDO , TO , TRPO , tryptamin 2,3-dioxygenase , tryptophan oxygenase , tryptophan pyrrolase , tryptophanase , tryptophan 2,3-dioxygenase , TDO-A , TO-A , TRPO-A , tryptamin 2,3-dioxygenase A , tryptophan 2,3-dioxygenase A , tryptophan oxygenase A , tryptophan pyrrolase A , tryptophanase A , tdo variant1 , tdo variant2 , tryptophan-2,3-dioxygenase , tryptophan-23-dioxygenase

GENE ID SPECIES
334082 Danio rerio
548450 Xenopus (Silurana) tropicalis
699739 Macaca mulatta
736252 Pan troglodytes
4456236 Ralstonia eutropha H16
4649802 Gramella forsetii KT0803
6776077 Alteromonas macleodii 'Deep ecotype'
8562285 Comamonas testosteroni CNB-2
100008541 Danio rerio
3256592 Cryptococcus neoformans var. neoformans JEC21
8617171 Dictyostelium discoideum AX4
8880228 Meiothermus ruber DSM 1279
10265555 Deinococcus proteolyticus MRP
10306071 Acidovorax avenae subsp. avenae ATCC 19860
10828127 Mesorhizobium opportunistum WSM2075
6999 Homo sapiens
475476 Canis lupus familiaris
56720 Mus musculus
64206 Rattus norvegicus
530397 Bos taurus
100344083 Oryctolagus cuniculus
100727713 Cavia porcellus
100301559 Sus scrofa
422409 Gallus gallus
495495 Xenopus laevis
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