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TDO2 Products

(Tryptophan 2,3-Dioxygenase (TDO2))

Categories

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012].

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Featured TDO2 Categories

TDO2 Antibodies

High quality antibodies with extensive validation data.

TDO2 ELISA Kits

Reliable ELISA kits for a wide range of species.

TDO2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TDO2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, IHC (p), WB
Validations
  • (10)
Cat. No. ABIN1501352
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human, Pig
Application IHC, WB
Validations
  • (7)
Cat. No. ABIN2782334
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (3)
Cat. No. ABIN520811
Quantity 50 μg
Datasheet Datasheet

Recommended TDO2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970915
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960224
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN511131
Quantity 96 tests
Datasheet Datasheet

Recommended TDO2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2733390
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3134222
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710470
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TDO2 products

Hao, Huang, Feng, Li, Wang, Wang, Wu, Wan, Zhang, Zhang: "Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomas." in: Journal of neuro-oncology, Vol. 144, Issue 1, pp. 11-20, (2019) (PubMed).

Wang, Do, Liu, Wang, Qu, Ke, Luo, Tang, Tang, Hu, Anderson, Liu, Gao: "Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps." in: The Journal of allergy and clinical immunology, Vol. 141, Issue 2, pp. 586-600.e6, (2018) (PubMed).

Woodling, Colas, Wang, Minhas, Panchal, Liang, Mhatre, Brown, Ko, Zagol-Ikapitte, van der Hart, Khroyan, Chuluun, Priyam, Milne, Rassoulpour, Boutaud, Manning-Boğ, Heller, Andreasson: "Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice." in: Brain : a journal of neurology, Vol. 139, Issue Pt 7, pp. 2063-81, (2016) (PubMed).

Guastella, Michelhaugh, Klinger, Kupsky, Polin, Muzik, Juhász, Mittal: "Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma." in: Molecular imaging, Vol. 15, (2016) (PubMed).

Novikov, Wang, Stanford, Parks, Ramirez-Cardenas, Landesman, Laklouk, Sarita-Reyes, Gusenleitner, Li, Monti, Manteiga, Lee, Sherr: "An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells." in: Molecular pharmacology, Vol. 90, Issue 5, pp. 674-688, (2016) (PubMed).

Bosnyák, Kamson, Guastella, Varadarajan, Robinette, Kupsky, Muzik, Michelhaugh, Mittal, Juhász: "Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas." in: Neuro-oncology, Vol. 17, Issue 9, pp. 1284-92, (2015) (PubMed).

Xiao, Li, Jones-Brando, Yolken: "Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strains." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 120, Issue 12, pp. 1631-9, (2013) (PubMed).

Ohira, Hagihara, Toyama, Takao, Kanai, Funakoshi, Nakamura, Miyakawa: "Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus." in: Molecular brain, Vol. 3, Issue 1, pp. 26, (2010) (PubMed).

Synonyms and alternative names related to TDO2

tryptophan 2,3-dioxygenase b (tdo2b), tryptophan 2,3-dioxygenase (tdo2), tryptophan 2,3-dioxygenase (TDO2), tryptophan 2,3-dioxygenase (MADE_02822), tryptophan 2,3-dioxygenase (CtCNB1_3657), tryptophan 2,3-dioxygenase a (tdo2a), tryptophan 2,3-dioxygenase (CNC04830), tryptophan 2,3-dioxygenase (tdo), tryptophan 2,3-dioxygenase (Mrub_2119), tryptophan 2,3-dioxygenase (Deipr_2235), tryptophan 2,3-dioxygenase (Acav_1166), tryptophan 2,3-dioxygenase (Mesop_4278), tryptophan 2,3-dioxygenase (Tdo2), tryptophan 2,3-dioxygenase L homeolog (tdo2.L), AA407491, chky, DDBDRAFT_0190495, DDBDRAFT_0231363, DDB_0190495, DDB_0231363, fb62b10, fi30d08, TDO, Tdo, Tdo2, TDO2, tdo2, tdo2l, TO, TPH2, TRPO, wu:fb62b10, wu:fi30d08, zgc:63488, zgc:103693

Protein level used designations for TDO2

  • TDO-B
  • TO-B
  • TRPO-B
  • tryptamin 2,3-dioxygenase B
  • tryptophan 2,3-dioxygenase B
  • tryptophan 2,3-dioxygenase, like
  • tryptophan oxygenase B
  • tryptophan pyrrolase B
  • tryptophanase B
  • TDO
  • TO
  • TRPO
  • tryptamin 2,3-dioxygenase
  • tryptophan oxygenase
  • tryptophan pyrrolase
  • tryptophanase
  • tryptophan 2,3-dioxygenase
  • TDO-A
  • TO-A
  • TRPO-A
  • tryptamin 2,3-dioxygenase A
  • tryptophan 2,3-dioxygenase A
  • tryptophan oxygenase A
  • tryptophan pyrrolase A
  • tryptophanase A
  • tdo variant1
  • tdo variant2
  • tryptophan-2,3-dioxygenase
  • tryptophan-23-dioxygenase
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