anti-Tyrosine Kinase, Non-Receptor, 1 (TNK1) Antibodies

The protein encoded by TNK1 belongs to the tyrosine protein kinase family. Additionally we are shipping TNK1 Kits (5) and TNK1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNK1 83813 Q99ML2
TNK1 8711 Q13470
TNK1 303247  
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Top anti-TNK1 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Guinea Pig Rabbit Un-conjugated WB Host: RabbitTarget Name: TNK1Antibody Dilution: 1.0ug/mlSample Tissue: RPMI-8226 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using TNK1 mouse mAb against truncated TNK1-His recombinant protein (1). Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma (A), liver carcinoma (B), breast carcinoma (C) and kiney carcinoma (D), showing nuclear localization with DAB staining using CHK2 mouse mAb. Dilution: 1:200~~1000 100 μL Log in to see 10 to 11 Days
$456.07
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-TNK1 pab (ABIN392113) in Hela cell line lysate. Dilution of anti-TNK1 was 1:100. dilution of secondary antibody (goat anti-rabbit-HRP) was 1:7000. Data and protocol courtesy of Dr. Richard Lu, Partners HealthCare System at Harvard University. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of TNK1 Antibody (ABIN652385) in T47D cell line lysates (35 µg/lane). TNK1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of L-540 cells, using Phospho-TNK1 (Tyr277) Antibody. ABIN6267199 at 1/100 staining Human thyroid cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IHC (p), WB TNK1 Antibody  western blot analysis in mouse brain cell line lysates (15ug/lane).This demonstrates the TNK1 antibody detected the TNK1 protein (arrow).(1:500) TNK1 Monoclonal( Ascites)  immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the TNK1 Monoclonal( Ascites) for immunohistochemistry.  Clinical relevance has not been evaluated. 0.1 mL Log in to see 10 to 11 Days
$385.00
Details
Mouse Mouse Un-conjugated WB TNK1 Antibody  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the TNK1 antibody detected the TNK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-Phospho-TNK1(Tyr277) Polyclonal Antibody, Unconjugated (ABIN746513) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$339.90
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-TNK1 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this ... 50 μg Log in to see 11 to 14 Days
$727.83
Details

Top referenced anti-TNK1 Antibodies

  1. Human Polyclonal TNK1 Primary Antibody for IHC (p), ELISA - ABIN544399 : Jhiang: The RET proto-oncogene in human cancers. in Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal TNK1 Primary Antibody for ELISA, WB - ABIN1724711 : Hoare, Hoare, Smith, Kalmaz, Small, Stratford May: Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. in Oncogene 2003 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal TNK1 Primary Antibody for IHC (p), WB - ABIN392113 : Henderson, Gonzales, Arora, Choudhary, Trent, Von Hoff, Mousses, Azorsa: High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells. in Molecular cancer research : MCR 2011 (PubMed)

More Antibodies against TNK1 Interaction Partners

Mouse (Murine) Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.

  2. data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity

  3. Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity

  4. cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter

Human Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied.

  2. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.

  3. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.

  4. Activated Tnk1 kinase is associated with Hodgkin's lymphoma.

  5. TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death.

TNK1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TNK1

  • tyrosine kinase non receptor 1 (TNK1) antibody
  • tyrosine kinase, non-receptor, 1 (Tnk1) antibody
  • tyrosine kinase non receptor 1 (Tnk1) antibody
  • Ack-like antibody
  • Kos1 antibody
  • Tnk1a antibody
  • Tnk1b antibody

Protein level used designations for TNK1

kinase of embryonic stem cells , non-receptor tyrosine kinase , non-receptor tyrosine-protein kinase TNK1 , CD38 negative kinase 1

GENE ID SPECIES
100061776 Equus caballus
83813 Mus musculus
8711 Homo sapiens
303247 Rattus norvegicus
510356 Bos taurus
489470 Canis lupus familiaris
100735628 Cavia porcellus
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