TNK1 Products
(Tyrosine Kinase, Non-Receptor, 1 (TNK1))
Categories
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Featured TNK1 Categories
TNK1 Antibodies
High quality antibodies with extensive validation data.
TNK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TNK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN392113
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7192841
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN1724711
Quantity
100 μL
Datasheet
Datasheet
Recommended TNK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886327
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5593936
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN2870179
Quantity
96 tests
Datasheet
Datasheet
Recommended TNK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323264
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3074517
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136967
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TNK1 products
: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).
: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).
: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1." in: Biochemical and biophysical research communications, Vol. 273, Issue 1, pp. 294-301, (2000) (PubMed).
Synonyms and alternative names related to TNK1
tyrosine kinase non receptor 1 (TNK1), tyrosine kinase, non-receptor, 1 (Tnk1), tyrosine kinase non receptor 1 (Tnk1), Ack-like, Kos1, Tnk1a, Tnk1bProtein level used designations for TNK1
- kinase of embryonic stem cells
- non-receptor tyrosine kinase
- non-receptor tyrosine-protein kinase TNK1
- CD38 negative kinase 1
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