TNK1 antibody (AA 451-560)

Catalog No. ABIN1724711

There are 2+ publications for this product available. The Mouse Monoclonal anti-TNK1 antibody is suitable to detect TNK1 in samples from Human. It has been validated for ELISA.

Quick Overview for TNK1 antibody (AA 451-560) (ABIN1724711)

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNK1 antibody is un-conjugated

Application: ELISA

Clone: 1B5G3

Product Details anti-TNK1 Antibody

Binding Specificity: AA 451-560

Purpose: TNK1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TNK1 antibody (ABIN1724711)

Azoitei, Brey, Busch, Fulda, Adler, Seufferlein: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).

Hoare, Hoare, Smith, Kalmaz, Small, Stratford May: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).

Target Details for TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Alternative Name: TNK1

Background: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Gene ID: 8711

UniProt: Q13470