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Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation.
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Human Polyclonal USP8 Primary Antibody for IHC, IHC (p) - ABIN4364004
Reincke, Sbiera, Hayakawa, Theodoropoulou, Osswald, Beuschlein, Meitinger, Mizuno-Yamasaki, Kawaguchi, Saeki, Tanaka, Wieland, Graf, Saeger, Ronchi, Allolio, Buchfelder, Strom, Fassnacht, Komada: Mutations in the deubiquitinase gene USP8 cause Cushing's disease. in Nature genetics 2014
Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A (show CLEC16A Antibodies), NRDP1 (show RNF41 Antibodies), and USP8 form tripartite complex; CLEC16A (show CLEC16A Antibodies)-NRDP1 (show RNF41 Antibodies)-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A (show CLEC16A Antibodies) = C-type lectin domain family 16 member A (show CLEC16A Antibodies); NRDP1 (show RNF41 Antibodies) = ubiquitin-protein ligase (show UBE2K Antibodies) NRDP1 (show RNF41 Antibodies); USP8 = ubiquitin specific peptidase 8)
the EGFR (show EGFR Antibodies)-USP8-trichoplein-Aurora A (show AURKA Antibodies) axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation
in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.
Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR (show EGFR Antibodies) expression.
Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.
Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.
Somatic USP8 gene mutations are a common cause of pediatric Cushing disease due to pituitary adenoma.
findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 (show BACE Antibodies) by deubiquitinating lysine 501.
USP8 regulates VEGFR2 (show KDR Antibodies) trafficking, signaling and proteolysis.
Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.
the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.
in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.
The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.
a role for the USP8.STAM (show STAM Antibodies) complex as a protective mechanism regulating early endosomal sorting of EGFR (show EGFR Antibodies) between pathways destined for lysosomal degradation and recycling.
USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.
in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired
Data indicate a novel mechanism where diacylglycerol kinase delta (show DGKD Antibodies) and protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) modulate the levels of ubiquitinated epidermal growth factor (show EGF Antibodies) receptors through Akt (show AKT1 Antibodies) and ubiquitin-specific protease 8.
deubiquitinating enzyme specifically expressed in testis (show XKR3 Antibodies), associates with the acrosome and centrosome in mouse germ cells
Results indicate that Nrdp1 (show RNF41 Antibodies) is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 (show RNF41 Antibodies) activity by mediating its stabilization.
We conclude that UBPY negatively regulates the rate of EGFR (show EGFR Antibodies) down-regulation by deubiquitinating EGFR (show EGFR Antibodies) on endosomes.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
ubiquitin carboxyl-terminal hydrolase 8
, ubiquitin-specific-processing protease 8
, ubiquitin specific peptidase 8
, ubiquitin carboxyl-terminal hydrolase 8-like
, deubiquitinating enzyme 8
, ubiquitin isopeptidase Y
, ubiquitin specific protease 8
, ubiquitin thioesterase 8
, ubiquitin thiolesterase 8
, putative deubiquitinating enzyme