anti-alpha Ketoglutarate Dehydrogenase (alphaKGDHC) Antibodies

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. Additionally we are shipping alpha Ketoglutarate Dehydrogenase Kits (37) and alpha Ketoglutarate Dehydrogenase Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
alphaKGDHC 360975 Q5XI78
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Top anti-alpha Ketoglutarate Dehydrogenase Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: OGDH Sample Tissue: Human DLD1 Antibody Dilution: 1.0ug/ml WB Suggested Anti-OGDH Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image OGDH antibody [C2C3], C-term detects OGDH protein at Mitochondria by immunofluorescent analysis. Sample: HeLa cells were fixed in -20℃ 100% MeOH for 5 min. Green: OGDH protein stained by OGDH antibody [C2C3], C-term , diluted at 1:500. Blue: Hoechst 33343 staining. IHC-P Image OGDH antibody [C2C3], C-term detects OGDH protein at mitochondria on mouse muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse muscle. OGDH antibody [C2C3], C-term , dilution: 1:500. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: OGDH Antibody [NBP1-84948] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: OGDH Antibody [NBP1-84948] - Staining of human cell line U-251MG shows positivity in mitochondria. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IHC (p), WB OGDH Antibody (C-term) (ABIN657365) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the OGDH antibody detected the OGDH protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: OGDH Antibody  - Immunofluorescent staining of human cell line U-251 MG shows localization to mitochondria. Immunohistochemistry-Paraffin: OGDH Antibody  - Staining of human heart muscle shows strong cytoplasmic positivity. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using OGDH antibody (ABIN5973793) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat ovary using OGDH antibody (ABIN5973793) at dilution of 1/100 (20x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IHC, WB ABIN6272971 at 1/100 staining Rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of mouse lung tissue, using OGDH antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details

More Antibodies against alpha Ketoglutarate Dehydrogenase Interaction Partners

Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. PIK3CA (show PIK3CA Antibodies) mutant cancer cells require PIK3CA (show PIK3CA Antibodies) but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

  2. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (show LIAS Antibodies)), which when mutated stabilize HIF1alpha (show HIF1A Antibodies) in a non-hydroxylated form.

  3. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  4. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  5. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  6. Reduction in the E2k (show DLST Antibodies) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL (show APOC4 Antibodies)-dependent manner

  2. Taken together, our results indicate that the redox sensing and ROS (show ROS1 Antibodies) forming properties of Pdh (show PDP Antibodies) and Ogdh are linked to S-glutathionylation

  3. pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2 (show GRX2 Antibodies). Taken together, our results demonstrate GSH and GSSG modulate ROS (show ROS1 Antibodies) production by Ogdh through S-glutathionylation of different subunits

  4. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  5. Alpha-ketoglutarate dehydrogenase is a primary site of ROS (show ROS1 Antibodies) production in normally functioning mitochondria.

  6. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

alpha Ketoglutarate Dehydrogenase (alphaKGDHC) Antigen Profile

Protein Summary

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate dehydrogenase (OGDH) antibody
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh) antibody
  • oxoglutarate dehydrogenase (Ogdh) antibody
  • 2210403E04Rik antibody
  • 2210412K19Rik antibody
  • AA409584 antibody
  • AKGDH antibody
  • d1401 antibody
  • E1k antibody
  • mKIAA4192 antibody
  • OGDC antibody

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

GENE ID SPECIES
426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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