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SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Antibodies (111) and SPINT2 Kits (11) and many more products for this protein.
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The expression of SPINT2 gene is regulated by its methylation status, and the methylation status of SPINT2 is altered by HPV infection. The aberrant methylation status of SPINT2 gene may play an important role in the development of cervical cancer.
aberrant methylation of the SPINT2 gene is frequently observed in high-grade gliomas and might confer MET signaling in the glioma cells.
finding of only one heterozygous SPINT2 mutation in 19 patients with isolated CA/GA was not statistically significant
In this work, KLK14 (show KLK14 Proteins) binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1 (show SPINT1 Proteins)) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 (show KLK14 Proteins) was successfully modeled.
limited role for HAI-2 in the inhibition of matriptase (show ST14 Proteins) and prostasin (show PRSS8 Proteins) is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin (show PRSS8 Proteins) or matriptase (show ST14 Proteins)
that the HAI-2 Kunitz domain 1 mutants influence the flux of matriptase (show ST14 Proteins) to the plasma membrane by affecting the oligomerization, maturation and/or folding of matriptase (show ST14 Proteins)
Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.
Concomitant presence of TMPRSS13 (show TMPRSS13 Proteins) with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.
This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene
study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)
Intestines of HAI-2 deficient mice showed altered expression of epithelial junctional proteins, including reduced levels of EpCAM (show EPCAM Proteins), E-cadherin (show CDH1 Proteins), occludin (show OCLN Proteins), claudin-1 (show CLDN1 Proteins) and -7, as well as an increased level of claudin-4 (show CLDN4 Proteins), indicating that the loss of HAI-2 compromises intestinal epithelial barrier function.
HAI-1 (show SPINT1 Proteins) regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.
mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1 (show SPINT1 Proteins)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.
HAI-1 (show SPINT1 Proteins) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
Unlike HAI-1 (show SPINT1 Proteins) and matriptase (show ST14 Proteins), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Proteins)
Inhibition of the transmembrane serine protease (show F2 Proteins) matriptase (show ST14 Proteins) (encoded by St14 (show ST14 Proteins)) is an essential function of HAI2 during tissue morphogenesis.
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
hepatocyte growth factor activator inhibitor type 2
, placental bikunin
, serine protease inhibitor, Kunitz type 2
, kunitz-type protease inhibitor 2
, serine protease inhibitor, Kunitz type, 2