serine Peptidase Inhibitor, Kunitz Type, 2 Proteins (SPINT2)

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Antibodies (111) and SPINT2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SPINT2 SPINT2 292770  
SPINT2 10653 O43291
SPINT2 20733 Q9WU03
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SPINT2 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Human Cells Human Fc Tag,ECD 10 μg Log in to see 20 to 21 Days
$250.80
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
Details
Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 13 to 16 Days
$492.31
Details
Human Cells Human His tag,ECD 50 μg Log in to see 20 to 21 Days
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human SPINT2 Protein. 100 μg Log in to see 11 to 18 Days
$596.97
Details

SPINT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , , , ,
Mouse (Murine) ,
,

More Proteins for serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. In this work, KLK14 (show KLK14 Proteins) binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1 (show SPINT1 Proteins)) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 (show KLK14 Proteins) was successfully modeled.

  2. limited role for HAI-2 in the inhibition of matriptase (show ST14 Proteins) and prostasin (show PRSS8 Proteins) is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin (show PRSS8 Proteins) or matriptase (show ST14 Proteins)

  3. that the HAI-2 Kunitz domain 1 mutants influence the flux of matriptase (show ST14 Proteins) to the plasma membrane by affecting the oligomerization, maturation and/or folding of matriptase (show ST14 Proteins)

  4. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.

  5. Concomitant presence of TMPRSS13 (show TMPRSS13 Proteins) with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.

  6. This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene

  7. study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)

  8. It suggests an involvement of SPINT2 in PCa (show FLVCR1 Proteins) tumorigenesis, probably in association with a post-translational regulation of SPINT2.

  9. N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases

  10. Matriptase (show ST14 Proteins) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. Intestines of HAI-2 deficient mice showed altered expression of epithelial junctional proteins, including reduced levels of EpCAM (show EPCAM Proteins), E-cadherin (show CDH1 Proteins), occludin (show OCLN Proteins), claudin-1 (show CLDN1 Proteins) and -7, as well as an increased level of claudin-4 (show CLDN4 Proteins), indicating that the loss of HAI-2 compromises intestinal epithelial barrier function.

  2. HAI-1 (show SPINT1 Proteins) regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.

  3. mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1 (show SPINT1 Proteins)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  4. HAI-1 (show SPINT1 Proteins) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  5. Unlike HAI-1 (show SPINT1 Proteins) and matriptase (show ST14 Proteins), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Proteins)

  6. Inhibition of the transmembrane serine protease (show F2 Proteins) matriptase (show ST14 Proteins) (encoded by St14 (show ST14 Proteins)) is an essential function of HAI2 during tissue morphogenesis.

SPINT2 Protein Profile

Protein Summary

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPINT2

  • serine peptidase inhibitor, Kunitz type, 2 (Spint2)
  • serine peptidase inhibitor, Kunitz type 2 (SPINT2)
  • serine protease inhibitor, Kunitz type 2 (Spint2)
  • AL024025 protein
  • C76321 protein
  • DIAR3 protein
  • HAI-2 protein
  • HAI2 protein
  • Kop protein
  • PB protein

Protein level used designations for SPINT2

hepatocyte growth factor activator inhibitor type 2 , placental bikunin , serine protease inhibitor, Kunitz type 2 , kunitz-type protease inhibitor 2 , serine protease inhibitor, Kunitz type, 2

GENE ID SPECIES
292770 Rattus norvegicus
10653 Homo sapiens
20733 Mus musculus
Selected quality suppliers for SPINT2 Proteins (SPINT2)
Did you look for something else?