Amifostine
Quick Overview for Amifostine (ABIN1027775)
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Purpose
- HIF-1α activator
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Characteristics
- Cellular protectant.
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Purity
- >98 %
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Chemical Name
- S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate
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Formula
- C5H15N2O3PS
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Solubility
- Soluble in water
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Comment
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Source: Synthetic.
Appearance: White Solid -
Restrictions
- For Research Use only
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Format
- Solid
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Precaution of Use
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
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Handling Advice
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
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Storage
- -20 °C
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Background
- Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents. Other effects include accelerated DNA repair, induction of cellular hypoxia, inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.
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Molecular Weight
- 214.22
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CAS-No
- 20537-88-6
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