R(-)-Gossypol
Catalog No. ABIN1027791
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Quick Overview for R(-)-Gossypol (ABIN1027791)
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Purpose
- Bcl-2 inhibitor
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Characteristics
- Bcl-2 inhibitor.
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Purity
- >98 %
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Chemical Name
- 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol
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Formula
- C30H30O8
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Solubility
- Soluble to 25 mM in ethanol and in DMSO.
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Comment
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Source: Synthetic.
Appearance: Dark Yellow Solid -
Restrictions
- For Research Use only
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Format
- Solid
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Precaution of Use
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H351 Precautionary Phrases: P281
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Handling Advice
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H351 Precautionary Phrases: P281
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Storage
- -20 °C
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Background
- Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin.
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Molecular Weight
- 518.56
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CAS-No
- 303-45-7
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