Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

omega-agatoxin IVA (omega-aga IVA or omega agatoxin IVA)

Catalog No. ABIN1540020
  • Target
    omega-agatoxin IVA
    Application
    Blocking Reagent (BR)
    Purpose
    omega-agatoxin IVA is a blocker of Cav2.1 channel
    Sequence
    Lys-Lys-Lys-Cys4-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys12-Lys-Trp-Gly-Gly-Thr-Pro-Cys19-Cys20-Arg-Gly-Arg-Gly-Cys25-Ile-Cys27-Ser-Ile-Met-Gly-Thr-Asn-Cys34-Glu-Cys36-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34)
  • Restrictions
    For Research Use only
  • Target
    omega-agatoxin IVA
    Background
    Omega-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that omega-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for omega-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the alpha-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
    Molecular Weight
    5198.44 Da
    CAS-No
    145017-83-0
You are here:
Support