Chlorotoxin

Catalog No. ABIN1540033

Quick Overview for Chlorotoxin (ABIN1540033)

Target: Chlorotoxin

Application: Blocking Reagent (BR)

Product Details

Purpose: Chlorotoxin is supposed to inhibit chloride channels

Sequence: Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2Disulfide bonds between Cys2-Cys19, Cys5-Cys28,Cys16-Cys33 and Cys20-Cys35

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: Chlorotoxin

Background: Chlorotoxin is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin binds to Cl-channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding.

Molecular Weight: 3995.8 Da

CAS-No: 163515-35-3