ShK

Catalog No. ABIN1540127

Quick Overview for ShK (ABIN1540127)

Target: Toxin ShK (Stoichactishelianthus potassium-channel reduced)

Application: Blocking Reagent (BR)

Product Details

Purpose: ShK is a Kv1.3 channel selective blocker

Sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OHDisulfid e bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: Toxin ShK (Stoichactishelianthus potassium-channel reduced)

Background: ShK has been isolated from the venom of the Carribean seaanemone Stoichactis helianthus. This toxin inhibits voltagedependentpotassium channels. It blocks Kv1.3 (KCNA3)potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6(KCNA6) respectively with 11 pM,16 pM and 165 pM.

Molecular Weight: 4054.85 Da