Tertiapin Q
Catalog No. ABIN1540134
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Quick Overview for Tertiapin Q (ABIN1540134)
Target
Tertiapin Q
Application
Blocking Reagent (BR)
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Purpose
- Tertiapin is a Kir channel blocker
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Sequence
- Ala-Leu-Cys3-Asn-Cys5-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys14-Trp-Lys-Lys-Cys18-Gly-Lys-Lys-NH2Disulfide bonds between Cys3-Cys14 and Cys5-Cys18
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Restrictions
- For Research Use only
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- Tertiapin Q
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Background
- Tertiapin has been isolated from the venom of the Honeybee Apis mellifera (African tarantula). Tertiapin-Q is a mutant of tertiapin where M13 has been mutated by Q in order to increase your stability. This is a neurotoxin with presynaptic activity that blocks the inwardly rectifying Kir1.1 (KCNJ1) and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of thesechannels in a 1:1 stoichiometry. Tertiapin-Q also inhibits calcium-activated large conductance BK-type (KCNMA/KCNMB) potassium channels in a concentration, and voltage-dependent manner, in addition to inhibiting Kir3.1/3.2 (KCNJ3/KCNJ6) heteromultimer potassiumchannels.
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Molecular Weight
- 2453.39 Da
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CAS-No
- 252198-49-5
Target
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