TMR-ShK

Catalog No. ABIN2566196

Quick Overview for TMR-ShK (ABIN2566196)

Target: TMR-ShK (TMR-Stichodactyla toxin)

Application: Blocking Reagent (BR)

Product Details

Sequence: AA sequence: TMR-AEEAc-Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser -Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser -Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys -Thr-Cys32-Gly-Thr-Cys35-OH Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32

Characteristics: Fluorescent (red) Kv1.3 blockerPotassium channel blocker

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

Expiry Date: 2 months

Target Details

Target: TMR-ShK (TMR-Stichodactyla toxin)

Background: TMR-ShK peptide toxin is a fluorescent labeled version of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks Kv1.3 and Kv1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing Kv1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress Kv1.3 channels. It can be used in confocal microscopy or FACS.

Molecular Weight: 4611.7 kDa