αC-conotoxin PrXA
Catalog No. ABIN2566212
$316.00
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Quick Overview for αC-conotoxin PrXA (ABIN2566212)
Application
Blocking Reagent (BR)
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Sequence
- AA sequence: Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-Hyp -Phe-Ser-Cys13-Ala-Gly-Leu-Arg-Gly-Gly- Cys20-Val-Leu-Pro-Hyp-Asn-Leu-Arg-Hyp-Lys- Phe-Lys-Glu-NH2 Disulfide bonds: Cys13-Cys20
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Characteristics
- Selective blocker of α1/β1/ε/δ and α1/β1/γ/δ nAChR subunits
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Restrictions
- For Research Use only
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Storage
- -20 °C
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Background
- αC-Conotoxin PrXA (AlphaC-PrXA) was originally isolated from the venom of the fish-hunting Conus parius. αC-Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface). The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom. αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.
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Molecular Weight
- 3541.1 kDa
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