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anti-Human ITCH Antibodies:
anti-Mouse (Murine) ITCH Antibodies:
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Human Monoclonal ITCH Primary Antibody for IF, WB - ABIN968414
Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. in Nature genetics 1998
Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN261096
Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. in Nature cell biology 2006
Human Polyclonal ITCH Primary Antibody for ICC, IF - ABIN4327763
Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. in International journal of cancer 2013
JunB (show JUNB Antibodies) neddylation mediated by Itch promotes its ubiquitination-dependent degradation.
Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Data show that the E3 ubiquitin ligase (show MUL1 Antibodies) Itch forms a complex with tricellulin (show MARVELD2 Antibodies) and thereby enhances its ubiquitination.
ASPP2 (show TP53BP2 Antibodies) suppresses invasion, peritoneal dissemination and TGF-beta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) by inhibiting Smad7 (show SMAD7 Antibodies) degradation mediated by ITCH in gastric cancer cells.
WBP2 (show WBP2 Antibodies)/ITCH signaling functions to link the intricate Wnt (show WNT2 Antibodies) and Hippo signaling networks in breast cancer.
The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (show RBM9 Antibodies) induced degradation of vFLIP.
Results indicate that TAX1BP1 (show TAX1BP1 Antibodies) functions as an adaptor molecule for Itch to target MAVS (show MAVS Antibodies) during RNA virus infection and thus restrict virus-induced apoptosis.
These data demonstrate that Itch, ubiquitin, and Alix (show PDCD6IP Antibodies) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.
The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain (show DRP2 Antibodies) of the host E3 ubiquitin ligase (show MUL1 Antibodies) ITCH.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
this study identified a previously unknown role for Itch in regulating IL-17 (show IL17A Antibodies)-mediated colonic inflammation and carcinogenesis
Itch monoubiquitinates SMN (show STMN1 Antibodies) and monoubiquitination of SMN (show STMN1 Antibodies) plays an important role in regulating its cellular localization.
ITCH targets TXNIP (show TXNIP Antibodies) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN Antibodies) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (show TNF Antibodies) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (show TNF Antibodies) signaling is genetically deleted.
ITCH modulates SIRT6 (show SIRT6 Antibodies) and SREBP2 (show SREBF2 Antibodies) to influence lipid metabolism and atherosclerosis in ApoE (show APOE Antibodies) null mice
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
The E3 ubiquitin ligase (show MUL1 Antibodies) Itch inhibits p38alpha (show MAPK14 Antibodies) signaling and skin inflammation through the ubiquitylation of Tab1 (show TAB1 Antibodies).
Ndfip1 (show NDFIP1 Antibodies) regulates itch ligase activity and airway inflammation via UbcH7 (show UBE2L3 Antibodies).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (show FOXP3 Antibodies) expression independently of Itch.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy