Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
data demonstrate the robust antitumor activity of these NKG2D ligand-binding bispecific proteins and support their further development for clinical use.
our results define cancer cell NKG2D as an important regulator of tumor initiation in ovarian cancer and presumably other malignancies and thus challenge current efforts in immunotherapy aimed at enhancing NKG2D function
Suggest NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome in kidney transplantation.
Data suggest that increased expression of NKG2D ligands after virus infection depends on interferon (show IFNA Proteins) response factors activated by the detection of viral double-stranded RNA by pattern-recognition receptors (RIG-I (show DDX58 Proteins)/MDA-5 (show IFIH1 Proteins)); NKG2D ligand up-regulation can be blocked by expression of viral dsRNA-binding proteins. (RIG-I (show DDX58 Proteins) = retinoic acid-inducible gene-I protein (show DDX58 Proteins); MDA5 (show IFIH1 Proteins) = melanoma differentiation associated protein-5 (show IFIH1 Proteins))
These data suggest that NKG2D gene polymorphisms may represent candidate biomarkers for the prediction of treatment-free remission (TFR (show TFRC Proteins)) of chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)) after dasatinib (Das (show ube3a Proteins)) treatment.
The authors demonstrate that HIV and specifically Nef and/or Vpu do not modulate CD155 (show PVR Proteins) on infected primary T cells and both CD155 (show PVR Proteins) and NKG2D ligands synergize as a natural killer cell receptor to trigger natural killer cell lysis of the infected cell.
Utilizing assays measuring cytolysis, the authors provide the first data implicating NKG2D in antibody-dependent NK cell responses against a target cell line either pulsed with gp120 (show ITIH4 Proteins) or infected with HIV-1.
tumoral NKG2D stimulates cell propagation and immune escape in acute myeloid leukemia (show BCL11A Proteins) cells
Data show that anti-VEGFR2 (vascular endothelial growth factor receptor 2 (show KDR Proteins)) antibody (mAb04) of fusion protein (mAb04-MICA (show MICA Proteins)) enhanced immunosurveillance activated by the NKG2D pathway.
these results demonstrate that NKG2D signaling is critical for maximal TNF-alpha (show TNF Proteins) release by NK cells
The adoptive transfer of NK1.1(-) CD4 (show CD4 Proteins)(+) NKG2D(+) cells suppressed DSS (show PMP22 Proteins)-induced colitis largely dependent on TGF-beta (show TGFB1 Proteins). Thus, NK1.1(-) CD4 (show CD4 Proteins)(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
IL-15 (show IL15 Proteins) mediated up-regulation of the activation receptor NKG2D and its adaptor DAP10 (show HCST Proteins) in B-1a cells indicating their essential coupling with IL-15 (show IL15 Proteins) receptor signaling pathway.
NKG2D is upregulated, and ROS (show ROS1 Proteins) and caspase-3 (show CASP3 Proteins) are inhibited by Strongylocentrotus nudus egg polysaccharide-enhanced antitumor 5-FU in mice
High NKG2D expression is associated with the Development of Bronchiolitis Obliterans.
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 (show RAE1 Proteins) family of NKG2D ligands. RAE-1 (show RAE1 Proteins) is transcriptionally repressed by histone deacetylase (show HDAC1 Proteins) inhibitor 3 (show PPP1R11 Proteins) (HDAC3 (show HDAC3 Proteins)) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Proteins) and preventing it from activating HDAC3 (show HDAC3 Proteins).
proposed that TLR9 (show TLR9 Proteins) regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors
data show that NKG2D has a nonredundant role in priming of CD8 (show CD8A Proteins)(+) T cells to produce antiviral cytokines
NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 (show TYROBP Proteins) complex
The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.
Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
killer cell lectin-like receptor subfamily K, member 1
, NKG2-D type II integral membrane protein-like
, NK cell receptor D
, NKG2-D type II integral membrane protein
, NKG2-D-activating NK receptor
, natural killer cell group 2D
, NK lectin-like receptor
, NKR-P2, ortholog of human NKG2D
, killer cell lectin-like receptor subfamily K member 1
, NKG2-D activating NK receptor