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anti-Human PYCARD Antibodies:
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Human Polyclonal PYCARD Primary Antibody for ICC, IF - ABIN4281803
Yao, Carlson, Sun, Ma, Wolf, Minei, Zang: Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. in PLoS ONE 2015
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Human Polyclonal PYCARD Primary Antibody for WB - ABIN610691
Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995
Show all 4 Pubmed References
Human PYCARD Primary Antibody for ELISA, WB - ABIN645848
Ansari, Dutta, Veettil, Dutta, Iqbal, Kumar, Roy, Chikoti, Singh, Chandran: Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses. in PLoS pathogens 2015
Human Polyclonal PYCARD Primary Antibody for IHC (p), IHC - ABIN257733
Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004
Human Polyclonal PYCARD Primary Antibody for ELISA, ICC - ABIN6264533
Wang, Zhang, Meng, Wang, Li, Liu, Liu: Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. in European journal of pharmacology 2018
Human Polyclonal PYCARD Primary Antibody for IHC, IHC (fro) - ABIN4281795
Doitsh, Galloway, Geng, Yang, Monroe, Zepeda, Hunt, Hatano, Sowinski, Muñoz-Arias, Greene: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. in Nature 2014
Human Polyclonal PYCARD Primary Antibody for WB - ABIN4281797
Siraj, Hussain, Al-Rasheed, Ahmed, Bavi, Alsobhi, Al-Nuaim, Uddin, Al-Kuraya: Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis. in The Journal of clinical endocrinology and metabolism 2011
Human Monoclonal PYCARD Primary Antibody for FACS, IHC - ABIN4281806
Peng, French, Tillman, Morgan, French: The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. in Experimental and molecular pathology 2014
results suggest that ASC, as a negative regulator of the MAVS (show MAVS Antibodies)-mediated innate immunity, may play an important role in host protection upon virus infection
PYCARD gene and its transcript variant may play a critical and regulative role in the inflflammatory response of primary gout patients with different phases and Chinese medicine syndromes.
ASC may be involved in tumor suppression and cell death via Bcl-2 (show BCL2 Antibodies) and phosphor Src (show SRC Antibodies).
Data show that in HK-2 (show HK2 Antibodies) cells and unilateral nephrectomy model, ASC expression level is significantly augmented after treatment with contrast media. Its silencing attenuates contrast-induced apoptosis in HK-2 (show HK2 Antibodies) cell.
ASC specks released by microglia bind to amyloid-beta and increase amyloid-beta oligomer and aggregate formation, acting as an inflammation-driven cross-seed for amyloid-beta pathology
ASC contributes to oral cavity squamous cell carcinoma metastasis, and high-level ASC expression is a marker for poor prognosis in OSCC patients
ASC CpG methylation may prove to be a primary regulator of the pathogenesis of chronic inflammatory diseases such as heart failure.
besides its role in the inhibition of the NF-kappaB (show NFKB1 Antibodies) pathway, NLRC3 (show NLRC3 Antibodies) interferes with the assembly and activity of the NALP3 (show NLRP3 Antibodies) inflammasome complex by competing with ASC for pro-caspase-1 (show CASP1 Antibodies) binding
ASC Induces Apoptosis via Activation of Caspase-9 (show CASP9 Antibodies) by Enhancing Gap Junction-Mediated Intercellular Communication.(
These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.
Cl(-) channel-dependent formation of dynamic ASC (show STS Antibodies) oligomers and inflammasome specks that remain inactive in the absence of K(+) efflux. Formed after Cl(-) efflux exclusively, ASC (show STS Antibodies) specks are NLRP3 (show NLRP3 Antibodies) dependent, reversible, and inactive, although they further prime inflammatory responses.
we found that butyrate significantly decreased Nlrp3 (show NLRP3 Antibodies) inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc (show STS Antibodies)(+/+)), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc (show STS Antibodies)(-/-)).
oligomerization of ASC (show STS Antibodies) creates a multitude of potential caspase-1 (show CASP1 Antibodies) activation sites, thus serving as a signal amplification mechanism for inflammasome-mediated cytokine production
Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1 (show CASP1 Antibodies)-dependent inflammasome and caspase-3 (show CASP3 Antibodies)/7 through an ASC (show STS Antibodies)-dependent mechanism.
ASC (show STS Antibodies) specks released by microglia bind to amyloid-beta and increase amyloid-beta oligomer and aggregate formation, acting as an inflammation-driven cross-seed for amyloid-beta pathology
results suggest that although Pyk2 (show PTK2B Antibodies) and FAK (show PTK2 Antibodies) are involved in inflammasome activation, only Pyk2 (show PTK2B Antibodies) directly phosphorylates ASC (show STS Antibodies) and brings ASC (show STS Antibodies) into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC (show STS Antibodies) speck formation and subsequent NLRP3 (show NLRP3 Antibodies) inflammation.
Alendronate (ALN (show TTC21B Antibodies))-augmented IL-1beta (show IL1B Antibodies) production and cell death require Smad3 (show SMAD3 Antibodies) and ASC (show STS Antibodies) activation, and SIS3 and anti-ASC (show STS Antibodies) antibodies may serve as palliative agents for necrotizing inflammatory diseases caused by ALN (show TTC21B Antibodies)
These data provide evidence that the inflammasome components ASC (show STS Antibodies), NLRP3 (show NLRP3 Antibodies) and AIM2 (show AIM2 Antibodies) play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.
SGLT-2 (show SLC5A2 Antibodies) inhibition with dapagliflozin reduces the activation of the Nlrp3 (show NLRP3 Antibodies)/ASC (show STS Antibodies) inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 (show DPP4 Antibodies) inhibitor Saxagliptin.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (show STS Antibodies), NLRP3 (show NLRP3 Antibodies), caspase 1 (show CASP1 Antibodies), thioredoxin interacting protein (show TXNIP Antibodies), and calreticulin (show CALR Antibodies) - a protein from endoplasmic reticulum, leading to IL-1beta (show IL1B Antibodies) synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta (show IL1B Antibodies) persists for hours after short-term exposures to elevated CO2
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein