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Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK-ULK1 (show ULK1 ELISA Kits) signaling dysregulation independently of HIF-1A (show HIF1A ELISA Kits).
Data indicate that nesfatin-1/NUCB-2 (show NUCB2 ELISA Kits) enhanced migration, invasion and epithelial-mesenchymal transition (EMT (show ITK ELISA Kits)) in colon cancer cells through LKB1 (show STK11 ELISA Kits)/AMPK/TORC1 (show CRTC1 ELISA Kits)/ZEB1 (show ZEB1 ELISA Kits) pathways in vitro and in vivo.
Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK phosphorylation in MC3T3-E1 cells.
AMP-activated protein kinase (AMPK (show PRKAA2 ELISA Kits)) regulates autophagy by phosphorylating BECN1 (show BECN1 ELISA Kits) at Thr388
activation of AMPK might be a stress response of host cells to restrict virus production through promotion of autophagic degradation
The results suggest that SESN2 (show SESN2 ELISA Kits) increases degradation of HIF-1A (show HIF1A ELISA Kits) via AMPK-PHD (show PDC ELISA Kits) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
These results demonstrate that Poly(ADP-ribosyl)ation of AMPK is a key early signal to efficiently convey extracellular nutrient perturbations with downstream events needed for the cell to optimize autophagic commitment before autophagosome formation.
Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3 (show DUSP6 ELISA Kits)) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa (show FLVCR1 ELISA Kits)) cells through sustained activation of both ERK1/2 (show MAPK1/3 ELISA Kits) and AMPKalpha (show GRK4 ELISA Kits).
vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 (show SIRT3 ELISA Kits) expression and AMPK phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3 (show SIRT3 ELISA Kits)/AMPK/autophagy network orchestrates in the protective effect of resveratrol in macrophages.
This review discusses the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition discussed are the mechanisms underlying the versatile roles of AMPK in diabetes and cancer. [review]
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 ELISA Kits)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 ELISA Kits) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 ELISA Kits)
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho (show KL ELISA Kits) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 ELISA Kits)-RUNX2 (show RUNX2 ELISA Kits) pathway.
AMPK-mTOR (show FRAP1 ELISA Kits)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP ELISA Kits)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 ELISA Kits)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 ELISA Kits)/TSC2 (show TSC2 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (show IGF1 ELISA Kits)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 ELISA Kits) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
AMPK regulates T cell survival and function. Demonstrate AMPK-dependent and independent rolesof AICAR (show ATIC ELISA Kits)/Compound C in regulating T cell responses.
AMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1 (show ZNF163 ELISA Kits)-OPN (show SPP1 ELISA Kits) axis.
PRKAA (show PRKAA2 ELISA Kits) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L (show DNM1L ELISA Kits).
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Thus we concluded that the AMPKalpha (show GRK4 ELISA Kits)-SIRT1 (show SIRT1 ELISA Kits) molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
AMPK activation inhibited IL-1beta (show IL1B ELISA Kits)-stimulated CXCL10 (show CXCL10 ELISA Kits) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4 (show IRAK4 ELISA Kits)) phosphorylation.
Findings indicate that the energy-sensing LKB1 (show STK11 ELISA Kits)-AMPK pathway regulates IGF1 (show IGF1 ELISA Kits) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R ELISA Kits)-PKB (show AKT2 ELISA Kits) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (show STK11 ELISA Kits)-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (show NME1 ELISA Kits) exists in a functional cellular complex with AMPK (show PRKAA2 ELISA Kits) and CFTR (show CFTR ELISA Kits) in airway epithelia, and NDPK-A (show NME1 ELISA Kits) catalytic function is required for the AMPK (show PRKAA2 ELISA Kits)-dependent regulation of CFTR (show CFTR ELISA Kits)
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit