ANAPC10 Proteins

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1\; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1\; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1\; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011].