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SARS-Coronavirus Membrane Protein (SARS-CoV M) (N-Term) antibody

The Rabbit Polyclonal anti- antibody has been validated for ELISA. It is suitable to detect in samples from SARS Coronavirus (SARS-CoV). There is 1 publication available.
Catalog No. ABIN1031552

Quick Overview for SARS-Coronavirus Membrane Protein (SARS-CoV M) (N-Term) antibody (ABIN1031552)

Target

See all SARS-Coronavirus Membrane Protein (SARS-CoV M) Antibodies
SARS-Coronavirus Membrane Protein (SARS-CoV M)

Reactivity

  • 7
  • 3
  • 1
SARS Coronavirus (SARS-CoV)

Host

  • 6
  • 4
Rabbit

Clonality

  • 6
  • 4
Polyclonal

Conjugate

  • 10
Un-conjugated

Application

  • 8
  • 5
ELISA
  • Binding Specificity

    • 2
    • 2
    • 1
    • 1
    N-Term

    Predicted Reactivity

    Predicted reactivity based on immunogen sequence: SARS-CoV2 Matrix protein: (identity 77%, homology 93%)

    Purification

    Affinity chromatography purified via peptide column

    Immunogen

    Anti-SARS-CoV Matrix antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of SARS-CoV Matrix protein.
    The immunogen is located within the first 50 amino acids of SARS-CoV Matrix.

    Isotype

    IgG
  • Application Notes

    SARS-CoV Matrix antibody can be used for the detection of SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μg/mL.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Antibody is supplied in PBS containing 0.02% sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

    Storage

    4 °C/-20 °C

    Storage Comment

    The antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year.

    Expiry Date

    12 months
  • Nuovo, Magro, Shaffer, Awad, Suster, Mikhail, He, Michaille, Liechty, Tili: "Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein." in: Annals of diagnostic pathology, Vol. 51, pp. 151682, (2020) (PubMed).

  • Target

    SARS-Coronavirus Membrane Protein (SARS-CoV M)

    Alternative Name

    SARS-CoV M Protein

    Target Type

    Viral Protein

    Background

    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope. It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design.

    Gene ID

    1489672

    NCBI Accession

    P59596
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