DGKA antibody

Catalog No. ABIN1042452

This anti-DGKA antibody is a Mouse Monoclonal antibody detecting DGKA in WB and IP. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for DGKA antibody (ABIN1042452)

Target: DGKA (Diacylglycerol Kinase, alpha 80kDa (DGKA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DGKA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: M6

Product Details anti-DGKA Antibody

Specificity: M6 is directed against the C-terminal portion (part of the catalytic domain) of rat DGKa.

Characteristics: Other

Purification: Purified

Application Details

Application Notes: M6 is useful for immunoprecipitation and western blot. Optimal antibody dilution should be determined by titration.

Comment:

M6 is a mouse monoclonal IgG1 antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with an Escherichia coli cell-expressed, affinity-purified glutathione S-transferase fusion protein of a C-terminal portion (part of the catalytic domain) of rat DGKu.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.09% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-DGKA antibody (ABIN1042452)

Guckes, McCarthy, Brahim: "Use of endosseous implants in a 3-year-old child with ectodermal dysplasia: case report and 5-year follow-up." in: Pediatric dentistry, Vol. 19, Issue 4, pp. 282-5, (1997) (PubMed).

Target Details for DGKA

Target: DGKA (Diacylglycerol Kinase, alpha 80kDa (DGKA))

Alternative Name: DGKa

Background: Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. Tissue specificity: lymphocytes and oligodendroglial cells. Diacylglycerol kinases are involved in cell signaling, either as regulators of diacylglycerol levels or as intracellular signal-generating enzymes.