GPR161 antibody (AA 1-28) (FITC)

Catalog No. ABIN1045543

This Rabbit Polyclonal antibody specifically detects GPR161 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for GPR161 antibody (AA 1-28) (FITC) (ABIN1045543)

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR161 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GPR161 Antibody (FITC)

Binding Specificity: AA 1-28

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human G-protein coupled receptor 161 protein (1-28AA)

Isotype: IgG

Application Details

Application Notes: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles. Product is photosensitive and should be protected from light.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GPR161

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Alternative Name: GPR161

Background:

Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Aliases: GPR161 antibody, G-protein coupled receptor 161 antibody, G-protein coupled receptor RE2 antibody

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process