Major Capsid Protein L1 antibody (Biotin)

Catalog No. ABIN1045684

This Rabbit Polyclonal antibody specifically detects in WB and ELISA. It exhibits reactivity toward Human Papillomavirus (HPV).

Quick Overview for Major Capsid Protein L1 antibody (Biotin) (ABIN1045684)

Target: Major Capsid Protein L1

Reactivity: Human Papillomavirus (HPV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: Western Blotting (WB), ELISA

Product Details

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant HPV18 Major capsid protein L1 protein

Isotype: IgG

Application Details

Application Notes: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.03 % Proclin 300, 50 % Glycerol, 0.01 M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.

Storage: -20 °C

Storage Comment: Shipped at 4 °C. Upon delivery aliquot and store at -24 °C or -84 °C.

Target Details

Target: Major Capsid Protein L1

Target Type: Viral Protein

Background: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Synonyms: L1

UniProt: P06794