Myc Target 1 antibody (C-Term)

Catalog No. ABIN1077374

Product Details anti-Myc Target 1 Antibody

Target: Myc Target 1 (MYCT1)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myc Target 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least two isoforms of MYCT1 are known to exist, this antibody will detect both isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: MYCT1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human MYCT1.

Isotype: IgG

Application Details

Application Notes: MYCT1 antibody can be used for detection of MYCT1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Comment:

(CT) Myc target protein 1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: MYCT1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for Myc Target 1

Target: Myc Target 1 (MYCT1)

Alternative Name: MYCT1 (MYCT1 Products)

Background: MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1.
Synonyms: Myc target protein 1, myc target in myeloid cells 1, MTLC, MT-MC1

Molecular Weight: 26 kDa

Gene ID: 80177

NCBI Accession: NP_079383