VTCN1 antibody

Catalog No. ABIN1077428

The Rabbit Monoclonal anti-VTCN1 antibody has been validated for WB and ELISA. It is suitable to detect VTCN1 in samples from Human and Mouse.

Quick Overview for VTCN1 antibody (ABIN1077428)

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This VTCN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-VTCN1 Antibody

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal VTCN1 antibody was raised against an 18 amino acid peptide near the center of human VTCN1.

Isotype: IgG

Application Details

Application Notes: VTCN1 antibody can be used for detection of VTCN1 by Western blot at 1 - 2 μg/mL.

Comment:

(IN) V-set domain containing T cell activation inhibitor 1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: VTCN1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for VTCN1

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Alternative Name: VTCN1

Background: T cell immunity plays a critical role in host immune surveillance of tumour cell growth and metastatic spread. VTCN1, also known as B7-H4, is a member of the B7 family of immune regulatory molecules. Expressed primarily on the membrane of lymphoid cells, VTCN1 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of VTCN1 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumour cells suppress T cell immunity and facilitate tumour progression. VTCN1 may thus be a useful biomarker for the early detection of ovarian cancer.
Synonyms: V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, B7-H4, B7H4, B7S1, B7X

Molecular Weight: 31 kDa (calculated)

Gene ID: 79679

NCBI Accession: NP_078902