CD59 antibody (N-Term)

Catalog No. ABIN1077443

The Rabbit Monoclonal anti-CD59 antibody has been validated for WB and ELISA. It is suitable to detect CD59 in samples from Human and Mouse.

Quick Overview for CD59 antibody (N-Term) (ABIN1077443)

Target: CD59

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD59 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD59 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal CD59 antibody was raised against a 14 amino acid peptide near the amino terminus of human CD59.

Isotype: IgG

Application Details

Application Notes: CD59 antibody can be used for detection of CD59 by Western blot at 1 - 2 μg/mL.

Comment:

(NT) CD59 molecule complement regulatory protein

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background: The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.
Synonyms: CD59 molecule complement regulatory protein, 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20

Molecular Weight: 14 kDa

Gene ID: 966

NCBI Accession: NP_000602

Pathways: Complement System