PPY antibody (AA 1-95)

Catalog No. ABIN1098139

This Mouse Monoclonal antibody specifically detects PPY in ELISA and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for PPY antibody (AA 1-95) (ABIN1098139)

Target: PPY (Pancreatic Polypeptide (PPY))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPY antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 2G5D12

Product Details anti-PPY Antibody

Binding Specificity: AA 1-95

Purpose: PPY Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PPY (AA: 1-95) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PPY antibody (ABIN1098139)

Banerjee, Onyuksel: "Human pancreatic polypeptide in a phospholipid-based micellar formulation." in: Pharmaceutical research, Vol. 29, Issue 6, pp. 1698-711, (2012) (PubMed).

Naessén, Carlström, Holst, Hellström, Hirschberg: "Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal." in: The American journal of clinical nutrition, Vol. 94, Issue 4, pp. 967-72, (2011) (PubMed).

Target Details for PPY

Target: PPY (Pancreatic Polypeptide (PPY))

Alternative Name: PPY

Background: This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products, the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.

Molecular Weight: 10.4 kDa

Gene ID: 5539

UniProt: P01298

Pathways: Feeding Behaviour