KEAP1 antibody (AA 380-624)

Catalog No. ABIN1098141

This anti-KEAP1 antibody is a Mouse Monoclonal antibody detecting KEAP1 in ELISA, IHC and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for KEAP1 antibody (AA 380-624) (ABIN1098141)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KEAP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 7G4B10

Product Details anti-KEAP1 Antibody

Binding Specificity: AA 380-624

Purpose: KEAP1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human KEAP1 (AA: 380-624 ) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KEAP1 antibody (ABIN1098141)

Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: "Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome." in: Epigenetics, Vol. 6, Issue 3, pp. 317-25, (2011) (PubMed).

Niture, Jaiswal: "INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis." in: Cell death and differentiation, Vol. 18, Issue 3, pp. 439-51, (2011) (PubMed).

Target Details for KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Alternative Name: KEAP1

Background: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Molecular Weight: 69.7 kDa

Gene ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location